Hu Shunfeng, Chu Yurou, Zhou Xiangxiang, Wang Xin
Department of Hematology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong 250021, China; Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong 250021, China.
Department of Hematology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong 250021, China.
Biomed Pharmacother. 2023 Oct;166:115419. doi: 10.1016/j.biopha.2023.115419. Epub 2023 Sep 4.
Ferroptosis is a recently recognized form of cell death with distinct features in terms of morphology, biochemistry, and molecular mechanisms. Unlike other types of cell death, ferroptosis is characterized by iron dependence, reactive oxygen species accumulation and lipid peroxidation. Recent studies have demonstrated that selective autophagy plays a vital role in the induction of ferroptosis, including ferritinophagy, lipophagy, clockophagy, and chaperone-mediated autophagy. Emerging evidence has indicated the involvement of ferroptosis in tumorigenesis through regulating various biological processes, including tumor growth, metastasis, stemness, drug resistance, and recurrence. Clinical and preclinical studies have found that novel therapies targeting ferroptosis exert great potential in the treatment of tumors. This review provides a comprehensive overview of the molecular mechanisms in ferroptosis, especially in autophagy-driven ferroptosis, discusses the recent advances in the biological roles of ferroptosis in tumorigenesis, and highlights the application of novel ferroptosis-targeted therapies in the clinical treatment of tumors.
铁死亡是一种最近才被认识到的细胞死亡形式，在形态学、生物化学和分子机制方面具有独特的特征。与其他类型的细胞死亡不同，铁死亡的特征是铁依赖性、活性氧积累和脂质过氧化。最近的研究表明，选择性自噬在铁死亡的诱导中起着至关重要的作用，包括铁蛋白自噬、脂自噬、生物钟自噬和伴侣介导的自噬。新出现的证据表明，铁死亡通过调节各种生物学过程，包括肿瘤生长、转移、干性、耐药性和复发，参与肿瘤发生。临床和临床前研究发现，针对铁死亡的新型疗法在肿瘤治疗中具有巨大潜力。本综述全面概述了铁死亡的分子机制，特别是自噬驱动的铁死亡，讨论了铁死亡在肿瘤发生中的生物学作用的最新进展，并强调了新型铁死亡靶向疗法在肿瘤临床治疗中的应用。
