Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Mailstop 0820, Bethesda, MD, 20892, USA.
LifeMine Therapeutics, 30 Acorn Park Dr., Cambridge, MA, 02140, USA.
Sci Rep. 2023 Jul 24;13(1):11944. doi: 10.1038/s41598-023-38042-8.
Chrysophaeum taylorii is a member of an understudied clade of marine algae that can be responsible for harmful coastal blooms and is known to accumulate bioactive natural products including antibiotics of the chrysophaentin class. Whole genome sequencing of laboratory-cultivated samples revealed an extensive and diverse complement of secondary metabolite biosynthetic genes in C. taylorii, alongside a small microbiome with a more limited biosynthetic potential. 16S microbiome analysis of laboratory cultured alongside wild-collected samples revealed several common taxa; however, analysis of biosynthetic genes suggested an algal origin for the chrysophaentins, possibly via one of several non-canonical polyketide synthase genes encoded within the genome.
泰勒角毛藻是海洋藻类中一个研究较少的分支的成员，它可导致有害的沿海水华，并已知积累生物活性天然产物，包括金角毛藻素类抗生素。实验室培养样本的全基因组测序显示，泰勒角毛藻中有大量多样化的次生代谢物生物合成基因，同时还有一个微生物组，其生物合成潜力有限。实验室培养的样本与野外采集的样本的 16S 微生物组分析显示出几个常见的分类群；然而，生物合成基因分析表明，金角毛藻素可能来自藻类，可能是通过基因组内编码的几种非典型聚酮合酶基因之一。
