具有抗心律失常活性的2-N-芳基烷基氨基-2-甲基-1-丙醇衍生物。
Derivatives of 2-N-arylalkylamino-2-methyl-1-propanol with antiarrhythmic activity.
作者信息
Eckstein M, Zajaczkowska J, Krupińska J, Michna M
出版信息
Pol J Pharmacol Pharm. 1986 Mar-Apr;38(2):215-20.
PMID:3748893
Abstract
Several aryl derivatives of achiral 2-amino-2-methyl-1-propanol have been obtained and tested for prophylactic and curative activity in different types of experimental arrhythmia. Interesting results were obtained for compounds 3 and 4 with activity and toxicity similar to those of quinidine.
摘要
已获得几种非手性2-氨基-2-甲基-1-丙醇的芳基衍生物，并在不同类型的实验性心律失常中测试了其预防和治疗活性。化合物3和4获得了有趣的结果，其活性和毒性与奎尼丁相似。
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