Tan Xin, Wang Zhongyi, Yang Xin, Yu Ping, Sun Manlin, Zhao Yuwei, Yu Haiyang
State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences, College of Stomatology, Chongqing Medical University, Chongqing, China.
Regen Biomater. 2023 Jul 12;10:rbad066. doi: 10.1093/rb/rbad066. eCollection 2023.
Glass-fibre-reinforced polyetherketoneketone (PEKK-GF) shows great potential for application as a dental implant restoration material; however, its surface bioinertness and poor antibacterial properties limit its integration with peri-implant soft tissue, which is critical in the long-term success of implant restoration. Herein, functional magnesium (Mg) and silver (Ag) ions were introduced into PEKK-GF by plasma immersion ion implantation (PIII). Surface characterization confirmed that the surface morphology of PEKK-GF was not visibly affected by PIII treatment. Further tests revealed that PIII changed the wettability and electrochemical environment of the PEKK-GF surface and enabled the release of Mg and Ag modulated by Giavanni effect. experiments showed that Mg/Ag PIII-treated PEKK-GF promoted the proliferation and adhesion of human gingival fibroblasts and upregulated the expression of adhesion-related genes and proteins. In addition, the treated samples inhibited the metabolic viability and adhesion of and on their surfaces, distorting bacterial morphology. Mg/Ag PIII surface treatment improved the soft tissue integration and antibacterial activities of PEKK-GF, which will further support and broaden its adoption in dentistry.
玻璃纤维增强聚醚酮酮（PEKK-GF）作为牙科种植体修复材料具有巨大的应用潜力；然而，其表面生物惰性和较差的抗菌性能限制了它与种植体周围软组织的整合，而这对种植体修复的长期成功至关重要。在此，通过等离子体浸没离子注入（PIII）将功能性镁（Mg）和银（Ag）离子引入PEKK-GF。表面表征证实PIII处理未明显影响PEKK-GF的表面形态。进一步测试表明，PIII改变了PEKK-GF表面的润湿性和电化学环境，并使Mg和Ag通过吉亚尼效应实现释放。实验表明，Mg/Ag PIII处理的PEKK-GF促进了人牙龈成纤维细胞的增殖和黏附，并上调了黏附相关基因和蛋白质的表达。此外，处理后的样品抑制了其表面金黄色葡萄球菌和大肠杆菌的代谢活力和黏附，使细菌形态发生扭曲。Mg/Ag PIII表面处理改善了PEKK-GF的软组织整合和抗菌活性，这将进一步支持并扩大其在牙科领域的应用。
