Escola Superior de Saúde, Instituto Politécnico do Porto, Rua Dr António Bernardino de Almeida, Porto, Portugal.
Centro de Investigação em Saúde e Ambiente, Escola Superior de Saúde, Instituto Politécnico do Porto, Rua Dr António Bernardino de Almeida, Porto, Portugal.
J Oncol Pharm Pract. 2024 Jul;30(5):893-901. doi: 10.1177/10781552231190025. Epub 2023 Jul 25.
Pharmacy professionals that manipulate cytotoxic drugs need to undergo educational programs, adopt the most convenient practices, and use appropriate equipment to avoid, as far as possible, occupational exposure to cytotoxic drugs. The main goal of this work is to characterize the education, technical practices, and attitudes towards cytotoxic drugs, of Portuguese pharmacy technicians. A questionnaire comprising eleven questions deemed pertinent was elaborated and subsequently validated by a pilot test. The anonymous, web-based survey was conducted between December 2022 and January 2023, by graduated pharmacy technicians that had manipulated cytotoxic drugs between 2017 and 2022. A total of 77 pharmacy technicians responded to the survey. Although sixty-six pharmacy technicians (86%) had been trained before beginning to manipulate cytotoxic drugs, the promotion of regular post-admission training by the institutions is sparse - only assumed by 53% of the pharmacy technicians ( = 41). All participants reported using gloves and gown during manipulation and the use of double gloves was common (99%; = 76). Compliances with the recommended limit time for uninterrupted manipulation activity (82%; = 63) and systematic double-checking (86%; = 66) were high, but the regular use of sterile gauze around syringe connection sites 58% ( = 45), was less frequent. None of the surveyed pharmacy technicians used closed-system transfer devices (CSTD) and 41 (53%) of those who used spikes did not thoughtfully use these devices. The implementation of regular training programs in manipulating cytotoxic drugs should be fostered, to promote the more judicious use of engineering controls and transversal adoption of the safest technical practices.
药剂师在操作细胞毒性药物时需要接受教育课程，采用最便捷的操作实践，并使用适当的设备，以尽可能避免职业性接触细胞毒性药物。本研究的主要目的是对葡萄牙药剂技术员的细胞毒性药物教育、技术操作和态度进行描述。我们设计了一份包含 11 个问题的问卷，并通过预试验对其进行了验证。这项匿名的网络调查于 2022 年 12 月至 2023 年 1 月期间进行，由 2017 年至 2022 年间操作过细胞毒性药物的药剂技术员完成。共有 77 名药剂技术员对该调查做出了回应。尽管 66 名药剂技术员（86%）在开始操作细胞毒性药物前接受过培训，但医疗机构很少定期提供入职后培训 - 仅 53%（ = 41）的药剂技术员认为有此必要。所有参与者在操作过程中均报告使用了手套和手术服，且双层手套的使用率较高（99%； = 76）。遵守推荐的不间断操作活动时间限制（82%； = 63）和系统的双次核对（86%； = 66）的合规率较高，但常规使用无菌纱布覆盖注射器连接部位的比例较低（58%； = 45）。没有接受调查的药剂技术员使用密闭式转移装置（CSTD），而 41 名（53%）使用过注射器的药剂技术员并没有明智地使用这些装置。应该促进细胞毒性药物操作常规培训计划的实施，以促进更合理地使用工程控制措施和横向采用最安全的技术操作。
