Zs-Nagy I
Mech Ageing Dev. 1979 Feb;9(3-4):237-46. doi: 10.1016/0047-6374(79)90102-7.
A survey of the available theoretical and experimental evidence is given regarding the cell membrane properties, such as the membrane fluidity, potassium permeability, etc., which are involved in the regulation of intracellular ion contents. These properties of the membrane undergo some age-dependent alterations in numerous cells studied so far, resulting in an increase of the intracellular potassium content. This phenomenon has a serious inhibitory effect on the rates of enzymatic catalyses involved in the protein synthesis, and may explain the decreased protein synthetic capacity of the old cells. Data are presented indicating that some changes in the membrane permeability are also involved in the malignant transformation of the cells; however, these are of opposite direction as compared to aging of cells. The "membrane hypothesis" of aging based on these facts seems to be a useful experimental approach to the problem of cellular aging.
针对细胞膜特性，如膜流动性、钾通透性等，给出了现有理论和实验证据的综述，这些特性参与细胞内离子含量的调节。迄今为止，在众多被研究的细胞中，膜的这些特性会经历一些与年龄相关的改变，导致细胞内钾含量增加。这种现象对参与蛋白质合成的酶催化速率具有严重的抑制作用，并且可能解释衰老细胞蛋白质合成能力下降的原因。所呈现的数据表明，膜通透性的一些变化也与细胞的恶性转化有关；然而，与细胞衰老相比，这些变化方向相反。基于这些事实的衰老“膜假说”似乎是解决细胞衰老问题的一种有用的实验方法。
