Laboratory for Applied Science and Technology in Health, Carlos Chagas Institute, Oswaldo Cruz Foundation (Fiocruz), Curitiba, Paraná, Brazil.
Department of Chemistry, Clemson University, 211 S. Palmetto Blvd, Clemson, 29634, SC, USA.
Anal Methods. 2023 Aug 3;15(30):3610-3630. doi: 10.1039/d3ay01081c.
Lateral flow assays (LFAs) have emerged as one of the most prominent paper-based biosensor platforms for rapidly detecting and quantifying analytes. Their selectivity, cost-effectiveness, efficiency, and simplicity make them ideal candidates for point-of-care (POC) applications, particularly when time-sensitive decisions are needed, such as cardiovascular events. The profound impact of cardiovascular diseases (CVDs), characterized by their high morbidity, mortality, and rehospitalization rates, necessitates an optimized approach for the early detection of cardiac muscle damage. This comprehensive review aims to consolidate the existing scientific literature on LFAs that specifically target cardiovascular biomarkers, including myoglobin and cardiac troponin I, over the past decade. By examining the advancements and findings in this field, valuable insights can be gained regarding the potential and future directions of LFAs in cardiovascular diagnostics.
侧向流检测（LFA）已经成为最突出的基于纸张的生物传感器平台之一，可用于快速检测和定量分析物。它们的选择性、成本效益、效率和简单性使它们成为即时护理（POC）应用的理想选择，特别是在需要做出时间敏感决策的情况下，例如心血管事件。心血管疾病（CVD）的深远影响，其特点是发病率、死亡率和再住院率高，因此需要优化方法来早期检测心肌损伤。本综述旨在整合过去十年中专门针对心血管生物标志物（包括肌红蛋白和心肌肌钙蛋白 I）的 LFA 的现有科学文献。通过研究该领域的进展和发现，可以深入了解 LFA 在心血管诊断中的潜力和未来方向。
