Program in Pathology, University of Mississippi Medical Center, Jackson, Mississippi, United States of America.
Department of Neurobiology and Anatomical Sciences, University of Mississippi Medical Center, Jackson, Mississippi, United States of America.
PLoS One. 2023 Jul 25;18(7):e0288868. doi: 10.1371/journal.pone.0288868. eCollection 2023.
Surgical weight loss procedures like vertical sleeve gastrectomy (SG) are sufficient in resolving obesity comorbidities and are touted to reduce the burden of pro-inflammatory cytokines and augment the release of anti-inflammatory cytokines. Recent reports suggest a reduced improvement in weight resolution after SG in Black Americans (BA) versus White Americans (WA). The goal of this study was to determine if differences in immunoglobulin levels and general markers of inflammation after SG in Black Americans (BA) and White Americans (WA) may contribute to this differential resolution.
Personal information, anthropometric data, and plasma samples were collected from 58 participants (24 BA and 34 WA) before and 6 weeks after SG for the measurement of immunoglobulin A (IgA), IgG, IgM, C-reactive protein (CRP), and transforming growth factor (TGFβ). Logistic regression analysis was used to determine the relationship of measures of body size and weight and inflammatory markers.
Both IgG and CRP were significantly elevated in BA in comparison to WA prior to weight loss. Collectively, IgG, TGFβ, and CRP were all significantly reduced at six weeks following SG. CRP levels in BA were reduced to a similar extent as WA, but IgG levels were more dramatically reduced in BA than WA despite the overall higher starting concentration. No change was observed in IgA and IgM.
These data suggest that SG improves markers of immune function in both BA and WA. More diverse markers of immune health should be studied in future work.
减重手术，如垂直袖状胃切除术（SG），足以解决肥胖合并症，并被认为可以减少促炎细胞因子的负担并增加抗炎细胞因子的释放。最近的报告表明，与白人相比，黑人接受 SG 后体重减轻的效果降低。本研究的目的是确定 SG 后黑人（BA）和白人（WA）之间免疫球蛋白水平和一般炎症标志物的差异是否导致这种差异的解决。
从 58 名参与者（24 名 BA 和 34 名 WA）中收集个人信息、人体测量数据和血浆样本，在 SG 前和 6 周后测量免疫球蛋白 A（IgA）、IgG、IgM、C 反应蛋白（CRP）和转化生长因子（TGFβ）。采用逻辑回归分析确定身体大小和体重及炎症标志物的关系。
在减肥前，与 WA 相比，BA 中的 IgG 和 CRP 均显著升高。总体而言，SG 后 6 周时 IgG、TGFβ 和 CRP 均显著降低。BA 的 CRP 水平降低到与 WA 相似的程度，但 BA 的 IgG 水平降低幅度明显大于 WA，尽管初始浓度较高。IgA 和 IgM 没有变化。
这些数据表明 SG 改善了 BA 和 WA 的免疫功能标志物。未来的研究应更多地研究免疫健康的不同标志物。
