Division of Neonatology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
J Perinatol. 2023 Oct;43(10):1308-1313. doi: 10.1038/s41372-023-01735-z. Epub 2023 Jul 25.
To characterize associations of the CDC Social Vulnerability Index (SVI) with medically attended acute respiratory illness among infants with bronchopulmonary dysplasia (BPD).
Retrospective cohort of 378 preterm infants with BPD from a single center. Multivariable logistic regression quantified associations of SVI with medically attended acute respiratory illness, defined as emergency department (ED) visits or hospital readmissions within a year after first hospital discharge. Mediation analysis quantified the extent to which differences in SVI may explain known Black-White disparities in medically attended acute respiratory illness.
SVI was associated with medically attended respiratory illness (per SVI standard deviation increment, aOR 1.44, 95% CI: 1.17-1.78). Adjustment for race and ethnicity attenuated the association (aOR 1.27, 95% CI: 0.97-1.64). SVI significantly mediated 31% of the Black-White disparity in ED visits (p = 0.04).
SVI was associated with, and may partially explain racial disparities in, medically attended acute respiratory illness among infants with BPD.
描述疾病预防控制中心社会脆弱性指数(SVI)与患有支气管肺发育不良(BPD)的婴儿中需要医疗干预的急性呼吸道疾病之间的关联。
这是一项单中心回顾性队列研究,纳入了 378 名患有 BPD 的早产儿。多变量逻辑回归分析了 SVI 与需要医疗干预的急性呼吸道疾病(定义为首次出院后一年内急诊就诊或再次住院)之间的关联。中介分析量化了 SVI 差异在多大程度上可以解释已知的黑人和白人在需要医疗干预的急性呼吸道疾病方面的差异。
SVI 与需要医疗干预的呼吸道疾病相关(SVI 每增加一个标准差,优势比 1.44,95%置信区间:1.17-1.78)。调整种族和民族因素后,这种关联减弱(优势比 1.27,95%置信区间:0.97-1.64)。SVI 显著介导了黑人-白人在急诊就诊方面 31%的差异(p=0.04)。
SVI 与患有 BPD 的婴儿中需要医疗干预的急性呼吸道疾病相关,并且可能部分解释了黑人和白人在这方面的差异。