由()-1-(苯并呋喃-2-基)乙-1-酮 - 甲基肟和碘苯合成()-2-(1-(甲氧基亚氨基)乙基)-2-苯基苯并呋喃-3(2)-酮——钯催化的去芳构化芳基化/氧化反应
Synthesis of ()-2-(1-(methoxyimino)ethyl)-2-phenylbenzofuran-3(2)-ones from ()-1-(benzofuran-2-yl)ethan-1-one -methyl oximes and iodobenzenes a palladium-catalyzed dearomative arylation/oxidation reaction.
作者信息
Zhu Wen-Jing, Yu Xiao, Liu Hong-Yan, Liu Yi, Zhao Jin-Bo, Zhang Peng-Fei, Xia Cheng-Cai, Li Fu-Rong
机构信息
School of Pharmacy College, Institute of Pharmacology, Shandong First Medical University & Shandong Academy of Medical Sciences, Tai'an, 271016, China.
College of Material, Chemistry and Chemical Engineering, Key Laboratory of Organosilicon Chemistry and Material Technology, Ministry of Education, Hangzhou Normal University, Hangzhou, 311121, China.
出版信息
Org Biomol Chem. 2023 Aug 9;21(31):6307-6311. doi: 10.1039/d3ob00772c.
A new method has been successfully developed that offers a facile and reliable approach for synthesizing ()-2-(1-(methoxyimino)ethyl)-2-phenylbenzofuran-3(2)-one, providing 28 compounds. This optimized process enables efficient preparation of a wide range of compounds using readily available ()-1-(benzofuran-2-yl)ethan-1-one -methyl oxime and iodobenzene, and provides alternative ideas for the structural modification of benzofuran ketones.
已成功开发出一种新方法，该方法为合成()-2-(1-(甲氧基亚氨基)乙基)-2-苯基苯并呋喃-3(2)-酮提供了一种简便可靠的途径，共得到28种化合物。这种优化后的方法能够使用易得的()-1-(苯并呋喃-2-基)乙-1-酮甲基肟和碘苯高效制备多种化合物，并为苯并呋喃酮的结构修饰提供了新的思路。
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