Rush D K
Pharmacol Biochem Behav. 1986 Jul;25(1):145-8. doi: 10.1016/0091-3057(86)90245-5.
Due to its stability and sensitivity, the Sidman avoidance schedule has been often used to characterize the psychotropic effects of drugs. In the present study, the effects of d-amphetamine (0.125, 0.25, and 0.5 mg/kg IM) on shuttlebox Sidman avoidance by rhesus monkeys were investigated. Amphetamine resulted in increased avoidance rates as shown by both bin and mean inter-response time (IRT) analyses. These results demonstrate the potential usefulness of this combination of task, species, and apparatus for investigating the effects of psychotropic substances. In addition, analysis of baseline data indicated a small but significant day of week effect with more efficient performance at the end of the week. The implications of this finding for conducting drug studies involving repeated measurements (i.e., cross-over designs) are discussed.
由于其稳定性和敏感性，西德曼回避程序常被用于表征药物的精神效应。在本研究中，研究了右旋苯丙胺（0.125、0.25和0.5mg/kg，肌肉注射）对恒河猴穿梭箱西德曼回避行为的影响。苯丙胺导致回避率增加，这在区间分析和平均反应间隔时间（IRT）分析中均有体现。这些结果证明了这种任务、物种和仪器组合对于研究精神活性物质效应的潜在有用性。此外，对基线数据的分析表明存在一个虽小但显著的星期效应，即周末的表现更高效。本文讨论了这一发现对进行涉及重复测量的药物研究（即交叉设计）的意义。
