Kuribara H
Pharmacol Biochem Behav. 1978 May;8(5):537-42. doi: 10.1016/0091-3057(78)90384-2.
The effects of d-amphetamine, caffeine, chlorpromazine, diazepam and and pentobarbital on Sidman avoidance responding (R-S interval, 30 sec; S-S interval, 3 sec) in rats, especially on the interresponse time (IRT) distribution, were studied. d-Amphetamine and caffeine increased the total number of responses. Short IRTs were increased, while longer ones were decreased. Chlorpromazine, diazepam and pentobarbital all increased the number of shocks delivered. After chlorpromazine, no marked change was observed in the total number of responses. However, response bursts and escape reponses increased, while IRTs between 3 and 30 sec decreased. After diazepam and pentobarbital, the burst response scarcely increased, and the IRTs in the 3-15 sec range decreased, while the IRTs longer than 33 sec increased. These changes were more marked after diazepam than after pentobarbital. Total number of responses was decreased by both drugs. The present results suggest that in utilizing the Sidman avoidance procedure for psychotropic drug assessment, changes in the IRT distribution give a more precise profile of the drug than is afforded by the total number of responses and shocks delivered.
研究了右旋苯丙胺、咖啡因、氯丙嗪、地西泮和戊巴比妥对大鼠西德曼回避反应（R-S间隔30秒；S-S间隔3秒）的影响，尤其考察了对反应间期（IRT）分布的影响。右旋苯丙胺和咖啡因增加了反应总数。短IRT增加，而长IRT减少。氯丙嗪、地西泮和戊巴比妥均增加了电击次数。给予氯丙嗪后，反应总数未观察到明显变化。然而，反应爆发和逃避反应增加，而3至30秒之间的IRT减少。给予地西泮和戊巴比妥后，爆发反应几乎没有增加，3至15秒范围内的IRT减少，而超过33秒的IRT增加。地西泮后的这些变化比戊巴比妥后的更明显。两种药物均使反应总数减少。目前的结果表明，在利用西德曼回避程序进行精神药物评估时，IRT分布的变化比反应总数和电击次数能更精确地反映药物的情况。
