Kumar Darshan, Rasheed Tazeen, Zuberi Bader Faiyaz, Sadaf Rabiah, Ali Faiza Sadaqat
Darshan Kumar (FCPS) Professor, Department of Medicine DIKIOHS, Dr. Ishrat-ul-Abad Institute of Oral Health Sciences, Dow University Health Sciences Karachi.
Dr. Tazeen Rasheed (FCPS) Associate Professor, Department of Medicine, Dow Medical College, Dow University of Health Sciences, Karachi, Pakistan.
Pak J Med Sci. 2023 Jul-Aug;39(4):956-960. doi: 10.12669/pjms.39.4.6964.
To determine correlation of HbA1c with serum iron and transferrin saturation in non-diabetic patients with iron deficiency.
This cross-sectional comparative study was conducted at Dr Ruth KM Pfau Civil Hospital Karachi from 15 September 2021 to 14 March 2022, on non-diabetic patients based on fasting blood sugar (FBS) of <100 mg/dl. Patients were divided into two groups. Group one included patients having iron deficiency anemia (ID), whereas group two included same number of age and sex matched healthy subjects taken as controls, without ID. Blood sample was taken for HbA1c, CBC, serum iron and total iron binding capacity. Transferrin saturation (TSAT) was calculated. Comparison of quantitative variables with ID and non-ID group was done by Student's t-test. Correlation of HbA1c with iron &TSAT was done in both groups using Kendal tau-b test, as data was not normally distributed.
Out of 230 patients, 83 (36.1%) were males while 147(63.9%) were females. Mean age of patients was 43.7±13.28 years. Mean HbA1c level was significantly high in ID group (5.89±0.43) as compared to non-ID group (5.52±0.50) with a p-value <.001. The HbA1c levels correlated negatively with hemoglobin, serum iron levels and transferrin saturation with a p-value <.001.
Low serum Iron and TSAT was related to elevation in HbA1c value. Iron deficiency needs to be corrected before HbA1c interpretation.
确定缺铁非糖尿病患者糖化血红蛋白（HbA1c）与血清铁及转铁蛋白饱和度之间的相关性。
本横断面比较研究于2021年9月15日至2022年3月14日在卡拉奇鲁思·KM·普法乌公民医院对空腹血糖（FBS）<100mg/dl的非糖尿病患者进行。患者分为两组。第一组包括缺铁性贫血（ID）患者，而第二组包括相同数量的年龄和性别匹配的健康受试者作为对照，无ID。采集血样检测HbA1c、全血细胞计数（CBC）、血清铁和总铁结合力。计算转铁蛋白饱和度（TSAT）。采用学生t检验对ID组和非ID组的定量变量进行比较。由于数据非正态分布，两组均使用肯德尔tau-b检验分析HbA1c与铁及TSAT的相关性。
230例患者中，男性83例（36.1%），女性147例（63.9%）。患者平均年龄为43.7±13.28岁。ID组的平均HbA1c水平（5.89±0.43）显著高于非ID组（5.52±0.50），p值<0.001。HbA1c水平与血红蛋白、血清铁水平和转铁蛋白饱和度呈负相关，p值<0.001。
低血清铁和TSAT与HbA1c值升高有关。在解读HbA1c之前需要纠正缺铁情况。
