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The Effects of Dietary Iron and Capsaicin on Hemoglobin, Blood Glucose, Insulin Tolerance, Cholesterol, and Triglycerides, in Healthy and Diabetic Wistar Rats.膳食铁和辣椒素对健康和糖尿病Wistar大鼠血红蛋白、血糖、胰岛素耐受性、胆固醇及甘油三酯的影响
PLoS One. 2016 Apr 11;11(4):e0152625. doi: 10.1371/journal.pone.0152625. eCollection 2016.
2
Oxidative stress, HDL functionality and effects of intravenous iron administration in women with iron deficiency anemia.氧化应激、高密度脂蛋白功能与缺铁性贫血女性静脉铁剂治疗的效果。
Clin Nutr. 2017 Apr;36(2):552-558. doi: 10.1016/j.clnu.2016.02.003. Epub 2016 Feb 13.
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The Relationship Between Lipoprotein-Associated Phospholipase A(2), Cholesteryl Ester Transfer Protein and Lipid Profile and Risk of Atherosclerosis in Women with Iron Deficiency Anaemia.缺铁性贫血女性中脂蛋白相关磷脂酶A2、胆固醇酯转运蛋白与血脂谱及动脉粥样硬化风险的关系
Clin Lab. 2015;61(10):1463-9. doi: 10.7754/clin.lab.2015.150202.
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Anaemia, a common but often unrecognized risk in diabetic patients: a review.贫血,糖尿病患者常见但常被忽视的风险:综述。
Diabetes Metab. 2015 Feb;41(1):18-27. doi: 10.1016/j.diabet.2014.06.001. Epub 2014 Jul 17.
5
Influence of iron deficiency anemia on hemoglobin A1c levels in diabetic individuals with controlled plasma glucose levels.缺铁性贫血对血糖水平得到控制的糖尿病患者糖化血红蛋白水平的影响。
Iran Biomed J. 2014;18(2):88-93. doi: 10.6091/ibj.1257.2014.
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Chronic kidney disease: global dimension and perspectives.慢性肾脏病:全球维度与展望。
Lancet. 2013 Jul 20;382(9888):260-72. doi: 10.1016/S0140-6736(13)60687-X. Epub 2013 May 31.
7
Influence of iron metabolism indices on HbA1c in non-diabetic pregnant women with and without iron-deficiency anemia: effect of iron supplementation.铁代谢指标对合并和未合并缺铁性贫血的非糖尿病孕妇糖化血红蛋白(HbA1c)的影响:铁补充剂的作用
Diabetes Metab Syndr. 2012 Apr-Jun;6(2):102-5. doi: 10.1016/j.dsx.2012.05.011. Epub 2012 Jun 28.
8
Comparisons of the iron deficient metabolic response in rats fed either an AIN-76 or AIN-93 based diet.比较以 AIN-76 或 AIN-93 为基础的饮食喂养的大鼠的缺铁代谢反应。
Nutr Metab (Lond). 2012 Oct 30;9(1):95. doi: 10.1186/1743-7075-9-95.
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Hepatic mTORC2 activates glycolysis and lipogenesis through Akt, glucokinase, and SREBP1c.肝 mTORC2 通过 Akt、葡萄糖激酶和 SREBP1c 激活糖酵解和脂肪生成。
Cell Metab. 2012 May 2;15(5):725-38. doi: 10.1016/j.cmet.2012.03.015. Epub 2012 Apr 19.
10
Enhanced expression of lipogenic genes may contribute to hyperglycemia and alterations in plasma lipids in response to dietary iron deficiency.脂肪生成基因的表达增强可能导致饮食缺铁时的高血糖和血浆脂质的改变。
Genes Nutr. 2012 Jul;7(3):415-25. doi: 10.1007/s12263-011-0278-y. Epub 2012 Jan 7.

缺铁性贫血与葡萄糖代谢

Iron deficiency anemia and glucose metabolism.

作者信息

Soliman Ashraf T, De Sanctis Vincenzo, Yassin Mohamed, Soliman Nada

机构信息

Department of Pediatrics, Alexandria University Children Hospital, Elchatby, Alexandria, Egypt.

出版信息

Acta Biomed. 2017 Apr 28;88(1):112-118. doi: 10.23750/abm.v88i1.6049.

DOI:10.23750/abm.v88i1.6049
PMID:28467345
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6166192/
Abstract

Iron deficiency anemia (IDA) is a global public health problem affecting both developing and developed countries with major consequences for human health as well as social and economic development. It occurs at all stages of the life cycle, but is more prevalent in pregnant women and young children. IDA appears to be more common in diabetic patients compared to non-diabetic population. Iron deficiency (ID) and IDA can impair glucose homeostasis in animals and human and may negatively affect glycemic control and predispose to more complications in diabetic patients. On the other hand diabetes and its complications are associated with anemia and its correction improves diabetes control and may prevent or delay the occurrence of complications. Physicians treating this form of anemia should be aware of its negative effect on glycemic control in normal and diabetic patients (both type 1 and type 2). They should prevent ID and treat early all those with IDA.This brief review aims to enlighten the different effects of IDA on glucose metabolism in normal and diabetic patients.

摘要

缺铁性贫血(IDA)是一个全球性的公共卫生问题,影响着发展中国家和发达国家,对人类健康以及社会和经济发展都有重大影响。它发生在生命周期的各个阶段,但在孕妇和幼儿中更为普遍。与非糖尿病人群相比,IDA在糖尿病患者中似乎更为常见。缺铁(ID)和IDA会损害动物和人类的葡萄糖稳态,并可能对血糖控制产生负面影响,使糖尿病患者更容易出现更多并发症。另一方面,糖尿病及其并发症与贫血有关,纠正贫血可改善糖尿病控制,并可能预防或延缓并发症的发生。治疗这种贫血形式的医生应该意识到它对正常和糖尿病患者(1型和2型)血糖控制的负面影响。他们应该预防ID,并尽早治疗所有IDA患者。本简要综述旨在阐明IDA对正常和糖尿病患者葡萄糖代谢的不同影响。