小鼠运动激活的基因差异。

Genetic differences in locomotor activation in mice.

作者信息

Crabbe J C

出版信息

Pharmacol Biochem Behav. 1986 Jul;25(1):289-92. doi: 10.1016/0091-3057(86)90267-4.

Abstract

Two highly inbred strains of mice were found to differ in habituation of activity repeatedly assessed in a toggle-box exploration task. The recombinant inbred (RI) strains derived from their cross resembled either one or the other parent strain, suggesting that a single gene exerts a marked influence on this behavior. The influence of an acute ethanol injection on activity in an open field was found to differ among 19 inbred strains. In 6 strains significant decreases in activity from the previous day's scores were seen; in two strains activity increased; and in 11 strains, no significant change was seen. Genetic specificity must, therefore, be considered in the interpretation of pharmacologic substrates for activity in mice. Lines of mice selectively bred for high and low open-field activity are suggested to offer an ideal subject population for neuropharmacologic studies.

摘要

在一项翻转箱探索任务中，对活动的习惯化进行反复评估时，发现两个高度近交的小鼠品系存在差异。由它们杂交产生的重组近交（RI）品系与亲本品系中的一个或另一个相似，这表明单个基因对这种行为有显著影响。研究发现，急性注射乙醇对19个近交系小鼠在旷场中的活动影响各不相同。在6个品系中，活动量较前一天的得分显著下降；在2个品系中活动量增加；而在11个品系中未观察到显著变化。因此，在解释小鼠活动的药理学底物时，必须考虑遗传特异性。有人建议，为高旷场活动和低旷场活动而选择性培育的小鼠品系，为神经药理学研究提供了理想的受试群体。