Freed W J, Crump S, Jeste D V
Pharmacol Biochem Behav. 1984 Jul;21(1):159-62. doi: 10.1016/0091-3057(84)90146-1.
The stimulation of motor activity by phencyclidine was found to differ significantly in BALB/c and C57Bl/6By inbred strains of mice. Phencyclidine-induced stimulation was compared for these strains, their reciprocal F1 hybrids, and their recombinant inbred offspring. There were significant differences in responsivity among the strains, suggesting a genetic influence on the PCP response; however, the strains did not segregate into two distinct groupings, suggesting that this genetic influence was not carried by a single gene. In addition, there was no relationship between the responsivity of these strains of mice to PCP and their previously-reported responses to amphetamine or scopolamine, which suggests that PCP-induced stimulation is not a simple cholinergic or amphetamine-like response.
已发现苯环利定对BALB/c和C57Bl/6By近交系小鼠运动活性的刺激存在显著差异。对这些品系、它们的正反交F1杂种以及它们的重组近交后代的苯环利定诱导刺激进行了比较。各品系之间的反应性存在显著差异，表明对苯环己哌啶反应存在遗传影响；然而，这些品系并未分成两个不同的组，这表明这种遗传影响不是由单个基因携带的。此外，这些品系小鼠对苯环利定的反应性与它们先前报道的对苯丙胺或东莨菪碱的反应之间没有关系，这表明苯环利定诱导的刺激不是简单的胆碱能或苯丙胺样反应。
