Allen P S, Castro M E, Treiber E O, Lunt J A, Boisvert D P
Phys Med Biol. 1986 Jul;31(7):699-711. doi: 10.1088/0031-9155/31/7/001.
Using CSF/protein solutions as models of vasogenic extracellular fluid, the concentration dependences of longitudinal and transverse proton relaxation rates have been measured at 37 degrees C and 100 MHz for the serum proteins, albumin, IgG, a 2.8:1 mixture of albumin and IgG and human serum itself. These measurements have been used to determine the sensitivity of proton relaxation rates to the amount and the type of the protein in oedema fluid, and to establish the significance of both of these factors in relation to a separation of vasogenic from cytotoxic oedema. An extension of the two-environment rapid-exchange model of solvent relaxation is presented, which accounts for the measurements on protein mixtures and which enables estimates to be made of the number and the transverse relaxation rate of water protons associated with the protein surface.
以脑脊液/蛋白质溶液作为血管源性细胞外液的模型，在37℃和100MHz条件下，测定了血清蛋白、白蛋白、免疫球蛋白G、白蛋白与免疫球蛋白G的2.8:1混合物以及人血清本身的纵向和横向质子弛豫率的浓度依赖性。这些测量结果已用于确定质子弛豫率对水肿液中蛋白质数量和类型的敏感性，并确定这两个因素在区分血管源性水肿和细胞毒性水肿方面的意义。本文提出了溶剂弛豫的双环境快速交换模型的扩展，该模型解释了对蛋白质混合物的测量结果，并能够估计与蛋白质表面相关的水质子的数量和横向弛豫率。
