Wang Mengru, Wu Juan, Wu Pan, Li Yuhong
Department of Cell Biology, Army Medical University, Chongqing 400038, China.
Genes Dis. 2022 May 31;10(5):1920-1936. doi: 10.1016/j.gendis.2022.05.015. eCollection 2023 Sep.
Circular RNAs (circRNAs) are a novel class of noncoding RNAs that widely exist in eukaryotes. As a new focus in the field of molecular regulation, circRNAs have attracted much attention in recent years. Previous studies have confirmed that circRNAs are associated with many physiological and pathological processes. CircRNAs also participate in the regulation of stem cells. Stem cells have the properties of self-renewal and differentiation, which make stem cell therapy popular. CircRNAs may serve as new targets in stem cell therapy due to their regulation in stem cells. However, the underlying relationships between circRNAs and stem cells are still being explored. In this review, we briefly summarize the effects of circRNAs on stem cells, in the context of biological activities, aging and apoptosis, and aberrant changes. Moreover, we also examine the biological roles of stem cell-derived exosomal circRNAs. We believe our review will provide insights into the effects of circRNAs on stem cells.
环状RNA（circRNAs）是一类新型的非编码RNA，广泛存在于真核生物中。作为分子调控领域的一个新热点，circRNAs近年来备受关注。以往的研究证实，circRNAs与许多生理和病理过程相关。circRNAs还参与干细胞的调控。干细胞具有自我更新和分化的特性，这使得干细胞治疗广受欢迎。由于circRNAs对干细胞的调控作用，它们可能成为干细胞治疗的新靶点。然而，circRNAs与干细胞之间的潜在关系仍在探索中。在这篇综述中，我们简要总结了circRNAs在生物活性、衰老和凋亡以及异常变化方面对干细胞的影响。此外，我们还研究了干细胞来源的外泌体circRNAs的生物学作用。我们相信我们的综述将为circRNAs对干细胞的影响提供见解。
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