Jiang Yong-Song, Wei Wei-Sheng, Xie Dao-Tao, Guo Gang
Department of Orthopedic, The Central Hospital of Yongzhou, Yongzhou 425000, Hunan Province, China.
Department of Orthopedic, Yongzhou Hospital Affiliated to University of South China, Yongzhou 425000, Hunan Province, China.
World J Stem Cells. 2025 May 26;17(5):101638. doi: 10.4252/wjsc.v17.i5.101638.
Circular RNAs (circRNAs) are a distinct type of nonlinear and noncoding RNAs endogenously expressed by pre-mRNA back-splicing and crucial in transcriptional and posttranscriptional regulation. CircRNAs can regulate cellular and molecular pathways through various mechanisms, such as microRNA sponging. Numerous studies have indicated the regulatory roles of circRNAs in the osteogenic differentiation of stem cells (SCs) isolated from different sources. Dental tissue-derived mesenchymal SCs (MSCs) have received considerable attention in artificial bone engineering, in which SCs are used to manufacture functional bone tissues to repair bone defects. Recently, studies have reported the regulatory roles of circRNAs in the osteogenic differentiation of dental-derived MSCs, such as apical papillae, dental pulp, and dental follicle SCs. This review aimed to discuss the findings of studies evaluating the contribution of circRNAs to the osteogenic differentiation of dental-derived MSCs.
环状RNA（circRNAs）是一类独特的非线性非编码RNA，通过前体mRNA反向剪接内源性表达，在转录和转录后调控中起关键作用。CircRNAs可通过多种机制调节细胞和分子途径，如微小RNA海绵作用。大量研究表明circRNAs在不同来源分离的干细胞（SCs）成骨分化中具有调节作用。牙组织来源的间充质干细胞（MSCs）在人工骨工程中受到了广泛关注，其中SCs被用于制造功能性骨组织以修复骨缺损。最近，研究报道了circRNAs在牙源性MSCs（如根尖乳头、牙髓和牙囊SCs）成骨分化中的调节作用。本综述旨在讨论评估circRNAs对牙源性MSCs成骨分化贡献的研究结果。
