King T R, Nance D M
Physiol Behav. 1986;37(3):475-81. doi: 10.1016/0031-9384(86)90209-x.
The role of the lateral septal area (LS) in the regulation of energy balance and the estrogenic control of feeding behavior in the female rat has been examined. Food intake (FI) and body weight (BWt) were measured daily following kainic acid (KA) LS lesions (KALS) to assess any regulatory changes in energy balance. In all animals KA lesions of the LS produced major cell loss in the LS; however the extent of damage was variable. Associated with KA lesions of the LS was the concurrent loss of CA3-CA4 cell groups in the hippocampus which was comparable for all the lesioned animals. The extent of septal damage was quantified morphometrically and correlated with changes in FI and BWt following estrogen treatment. The significant effects of the KALS lesions, relative to the control animals were: an increase in BWt which was statistically significant 22 days following brain surgery, an increase in daily FI which was significant by day 6 post surgery, an attenuation in the anorexic effects of estrogen on FI and BWt, and a significant decrease in the present days of vaginal estrus. Moreover, the anorexic effects of estrogen were significantly correlated with the extent of LS damage, but not the amount of hippocampal damage. The present study confirms that an increase in BWt is produced by KA lesions of the LS and further indicates that a sustained period of increased FI precedes the increase in BWt.(ABSTRACT TRUNCATED AT 250 WORDS)
已对外侧隔区（LS）在雌性大鼠能量平衡调节及雌激素对摄食行为控制中的作用进行了研究。在用海藻酸（KA）损毁LS（KALS）后，每日测量食物摄入量（FI）和体重（BWt），以评估能量平衡的任何调节变化。在所有动物中，LS的KA损毁导致LS内大量细胞丢失；然而，损伤程度各不相同。与LS的KA损毁相关的是海马体中CA3-CA4细胞群同时丢失，这在所有受损动物中情况相当。通过形态计量学对隔区损伤程度进行量化，并与雌激素处理后FI和BWt的变化相关联。与对照动物相比，KALS损毁的显著影响包括：脑手术后22天BWt增加具有统计学意义，术后第6天每日FI增加显著，雌激素对FI和BWt的厌食作用减弱，以及阴道发情天数显著减少。此外，雌激素的厌食作用与LS损伤程度显著相关，但与海马体损伤量无关。本研究证实，LS的KA损毁会导致BWt增加，并进一步表明在BWt增加之前，FI会持续增加一段时间。（摘要截短于250字）
