Institute of Regenerative Medicine and Laboratory Technology Innovation, Qingdao University, Qingdao, Shandong 266071, PR China.
Blood Purification Department, Qingdao Hospital of Traditional Chinese Medicine, Qingdao Hiser Hospital, Qingdao, Shandong 266071, PR China.
Biomed Pharmacother. 2023 Sep;165:115206. doi: 10.1016/j.biopha.2023.115206. Epub 2023 Jul 24.
Corneal epithelial defects and excessive wound healing might lead to severe complications. As stem cells can self-renew infinitely, they are a promising solution for regenerating the corneal epithelium and treating severe corneal epithelial injury. The chemical and biophysical properties of biological scaffolds, such as the amniotic membrane, fibrin, and hydrogels, can provide the necessary signals for stem cell proliferation and differentiation. Multiple researchers have conducted investigations on these scaffolds and evaluated them as potential therapeutic interventions for corneal disorders. These studies have identified various inherent benefits and drawbacks associated with these scaffolds. In this study, we provided a comprehensive overview of the history and use of various stem cells in corneal repair. We mainly discussed biological scaffolds that are used in stem cell transplantation and innovative materials that are under investigation.
角膜上皮缺损和过度愈合可能导致严重的并发症。由于干细胞可以无限自我更新，因此它们是再生角膜上皮和治疗严重角膜上皮损伤的有前途的解决方案。生物支架的化学和物理特性，如羊膜、纤维蛋白和水凝胶，可以为干细胞的增殖和分化提供必要的信号。许多研究人员已经对这些支架进行了研究，并将其评估为治疗角膜疾病的潜在治疗干预措施。这些研究确定了与这些支架相关的各种固有优点和缺点。在本研究中，我们全面回顾了各种干细胞在角膜修复中的历史和应用。我们主要讨论了用于干细胞移植的生物支架和正在研究的创新材料。
