美国国家健康和营养调查研究 2005-2008 年糖尿病视网膜病变患者的抑郁状况
Depression in Individuals With Diabetic Retinopathy in the US National Health and Nutrition Examination Survey, 2005-2008.
机构信息
Department of Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, New York, USA (G.V., A.C., J.K., A.D., S.A.).
Department of Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, New York, USA (G.V., A.C., J.K., A.D., S.A.).
出版信息
Am J Ophthalmol. 2023 Dec;256:63-69. doi: 10.1016/j.ajo.2023.07.005. Epub 2023 Jul 24.
PURPOSE
To examine the relationship between diabetic retinopathy (DR) and depression in the United States.
DESIGN
Retrospective, cross-sectional study.
METHODS
National Health and Nutrition Examination Survey (NHANES) participants between 2005 and 2008 (ages 40-85 years) were included. Prevalence of major depression among DR stages as determined by retinal imaging was estimated. Multivariable models assessed associations between depression and DR.
RESULTS
Depression was more common in those with moderate to severe DR (16%) than in those with no DR (7%), mild nonproliferative diabetic retinopathy (NPDR, 6%), or proliferative DR (5%). In a model with DR stages that adjusted for demographic factors, there was an association between moderate to severe DR and depression (odds ratio [OR], 2.46, 95% CI, 1.03-5.85).
CONCLUSIONS
Depression was more prevalent in those with moderate to severe NPDR than in those with no DR, mild NPDR, or proliferative DR. This relationship is statistically significant after adjustment for demographic factors.
目的
在美国研究糖尿病视网膜病变（DR）与抑郁症之间的关系。
设计
回顾性、横断面研究。
方法
纳入 2005 年至 2008 年（40-85 岁）的国家健康和营养调查（NHANES）参与者。根据视网膜成像确定的 DR 各阶段的重度抑郁症患病率。多变量模型评估了抑郁症与 DR 之间的关联。
结果
与无 DR、轻度非增生性糖尿病视网膜病变（NPDR）或增生性 DR 相比，中度至重度 DR 患者（16%）更常见抑郁症（7%、6%和 5%）。在一个调整了人口统计学因素的 DR 阶段模型中，中度至重度 DR 与抑郁症之间存在关联（比值比 [OR]，2.46，95%CI，1.03-5.85）。
结论
与无 DR、轻度 NPDR 或增生性 DR 相比，中度至重度 NPDR 患者中抑郁症更为普遍。在调整人口统计学因素后，这种关系具有统计学意义。
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