Zhao Xiaopeng, Tian Zheng, Sun Mingli, Dong Dan
College of Exercise and Health, Shenyang Sport University, Shenyang, Liaoning, 110102, China.
Department of Pathophysiology, College of Basic Medical Science, China Medical University, Shenyang, Liaoning, 110122, China.
Cell Death Discov. 2023 Jul 26;9(1):261. doi: 10.1038/s41420-023-01565-0.
Being a broad-spectrum anticancer drug, doxorubicin is indispensable for clinical treatment. Unexpectedly, its cardiotoxic side effects have proven to be a formidable obstacle. Numerous studies are currently devoted to elucidating the pathological mechanisms underlying doxorubicin-induced cardiotoxicity. Nrf2 has always played a crucial role in oxidative stress, but numerous studies have demonstrated that it also plays a vital part in pathological mechanisms like cell death and inflammation. Numerous studies on the pathological mechanisms associated with doxorubicin-induced cardiotoxicity demonstrate this. Several clinical drugs, natural and synthetic compounds, as well as small molecule RNAs have been demonstrated to prevent doxorubicin-induced cardiotoxicity by activating Nrf2. Consequently, this study emphasizes the introduction of Nrf2, discusses the role of Nrf2 in doxorubicin-induced cardiotoxicity, and concludes with a summary of the therapeutic modalities targeting Nrf2 to ameliorate doxorubicin-induced cardiotoxicity, highlighting the potential value of Nrf2 in doxorubicin-induced cardiotoxicity.
作为一种广谱抗癌药物，阿霉素在临床治疗中不可或缺。出乎意料的是，其心脏毒性副作用已被证明是一个巨大的障碍。目前有许多研究致力于阐明阿霉素诱导心脏毒性的病理机制。Nrf2在氧化应激中一直起着关键作用，但大量研究表明，它在细胞死亡和炎症等病理机制中也起着至关重要的作用。关于阿霉素诱导心脏毒性相关病理机制的众多研究证明了这一点。几种临床药物、天然和合成化合物以及小分子RNA已被证明可通过激活Nrf2来预防阿霉素诱导的心脏毒性。因此，本研究着重介绍Nrf2，讨论Nrf2在阿霉素诱导心脏毒性中的作用，并总结针对Nrf2改善阿霉素诱导心脏毒性的治疗方式，突出Nrf2在阿霉素诱导心脏毒性中的潜在价值。
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