Department of Internal Medicine, College of Medicine, Jouf University, Sakaka, Kingdom of Saudi Arabia.
Department of Gynecology and Obstetrics, College of Medicine, Jouf University, Sakaka, Kingdom of Saudi Arabia.
J Int Med Res. 2024 Oct;52(10):3000605241279190. doi: 10.1177/03000605241279190.
Cardiovascular disease (CVD) is the leading cause of morbidity and mortality for both men and women among all ethnicities worldwide. Although significant improvements in the management of CVD occurred in the 20th century, non-invasive, universal, early diagnostic biomarkers and newer therapeutic drugs are needed for clinical treatment by physicians. MicroRNAs (miRNAs) are a class of endogenous, non-coding, single-stranded, small RNA molecules that are critically controlled by all human biological processes. Moreover, dysregulated miRNA expression is directly involved in various CVDs, including stable coronary artery disease and acute coronary syndrome. Several miRNAs that are enriched in the plasma of CVD patients have potential as clinical biomarkers, and overexpression or inhibition of specific miRNAs has novel therapeutic significance in the management of CVD. Aging is a multifactorial physiological process that gradually deteriorates tissue and organ function and is considered a non-modifiable major risk factor for CVDs. Recently, several studies established that various miRNAs essentially regulate aging and aging-related disease processes. This narrative review briefly discusses the recently updated molecular involvement of miRNAs in CVDs, their possible diagnostic, prognostic, and therapeutic value, and their relationship to the aging process.
心血管疾病 (CVD) 是全球所有种族男性和女性发病率和死亡率的主要原因。尽管 20 世纪 CVD 的管理取得了重大进展，但医生的临床治疗仍需要非侵入性、通用、早期诊断的生物标志物和新型治疗药物。MicroRNAs (miRNAs) 是一类内源性、非编码、单链、小 RNA 分子，它们对所有人类生物过程都有严格的控制。此外，miRNA 表达失调直接参与各种 CVD，包括稳定型冠状动脉疾病和急性冠状动脉综合征。在 CVD 患者血浆中富集的几种 miRNA 具有作为临床生物标志物的潜力，并且特定 miRNA 的过表达或抑制在 CVD 的管理中具有新的治疗意义。衰老 是一个多因素的生理过程，它逐渐恶化组织和器官的功能，被认为是 CVD 的一个不可改变的主要危险因素。最近，几项研究证实，各种 miRNA 主要调节衰老和与衰老相关的疾病过程。本综述简要讨论了 miRNA 最近在 CVD 中的分子作用，及其在诊断、预后和治疗方面的可能价值，以及它们与衰老过程的关系。
