Huang Lining, Pan Ying, Zhou Kaixin, Liu Hongying, Zhong Shao
Department of Endocrinology, Gusu School, Nanjing Medical University, The First People's Hospital of Kunshan, Kunshan, 215300, People's Republic of China.
Guangzhou Laboratory, Guangzhou, 510005, People's Republic of China.
Int J Gen Med. 2023 Jul 21;16:3083-3094. doi: 10.2147/IJGM.S418520. eCollection 2023.
Diabetes mellitus is a metabolic disorder with a complex etiology in which glycemic dynamics are disturbed and the body is unable to maintain the process of glucose homeostasis through the pancreas. Persistent symptoms of high blood glucose or low blood glucose may lead to diabetic complications, such as neuropathy, nephropathy, retinopathy, and cardiovascular diseases. Glycemic variability which can represent the presence of excessive glycemic excursions is an indicator for evaluating glucose homoeostasis. Limiting glycemic variability has gradually become an emerging therapeutic target in improve diabetes metabolism and prevent associated complications. This article reviews the progress of research on the various quantifiable parameters of glycemic variability and their relationships with vascular lesions and mechanisms.
糖尿病是一种病因复杂的代谢紊乱疾病，其中血糖动态受到干扰，身体无法通过胰腺维持葡萄糖稳态过程。持续的高血糖或低血糖症状可能导致糖尿病并发症，如神经病变、肾病、视网膜病变和心血管疾病。血糖变异性可代表血糖过度波动的存在，是评估葡萄糖稳态的一个指标。限制血糖变异性已逐渐成为改善糖尿病代谢和预防相关并发症的一个新兴治疗靶点。本文综述了血糖变异性各种可量化参数的研究进展及其与血管病变和机制的关系。
