AIM: This case series elaborates on the importance, advantages, and clinical applications of removable partial dentures as prosthetic rehabilitation in pediatric dental patients. BACKGROUND: Tooth loss in children is a measure of dental disease with multiple determinants. There are several potential sequelae as a result of tooth loss. Early treatment and follow-up are the keys to the successful rehabilitation of young patients with missing teeth. It is critical that oral rehabilitation is started early to maintain and correct oral functions. Removable prostheses are the commonly selected treatment options for young patients because of the continuous growth and development of maxillary and mandibular bones. Dental prosthetic appliances in pediatrics must be planned with respect to the special conditions that lead to tooth loss or damage. CASE DESCRIPTION: The present case series is a compilation of four cases describing the esthetic, functional, and psychological rehabilitation of children with missing teeth, either hereditary/genetic (ectodermal dysplasia) or due to premature tooth loss (trauma). CONCLUSION: Prosthetic rehabilitation with a removable partial denture in children requires a specific management strategy. A multidisciplinary approach is needed under the constant supervision of pediatric dentists as well as regular check-ups with clinical and radiographical examinations. HOW TO CITE THIS ARTICLE: Goswami M, Chauhan N. Prosthetic Management with Removable Partial Dentures in Pediatric Dental Care: Case Series. Int J Clin Pediatr Dent 2023;16(3):534-540.