Miller M W
Science. 1986 Sep 19;233(4770):1308-11. doi: 10.1126/science.3749878.
Prenatal exposure to alcohol produces many developmental defects of the central nervous system, such as microcephaly, mental retardation, motor dysfunction, and cognitive deficiencies. Therefore, the generation of neurons in the cerebral cortex was examined in the offspring of female rats fed a diet containing ethanol. Prenatal exposure to ethanol delayed and extended the period during which cortical neurons were generated, reduced the number of neurons in the nature cortex with the same time of origin, and altered the distribution of neurons generated on a particular day. Thus, the proliferation and migration of cortical neurons are profoundly affected by in utero exposure to ethanol.
孕期接触酒精会导致中枢神经系统出现多种发育缺陷，如小头畸形、智力迟钝、运动功能障碍和认知缺陷。因此，研究人员对喂食含乙醇饮食的雌性大鼠后代的大脑皮质神经元生成情况进行了检测。孕期接触乙醇会延迟并延长皮质神经元的生成期，减少同一起源时间自然皮质中的神经元数量，并改变特定日期生成的神经元分布。因此，子宫内接触乙醇会对皮质神经元的增殖和迁移产生深远影响。
