Xu Hongge, Ding Hongyan, Shi Can, Ge Qianqian
Department of Gynecology, The Affiliated Huai'an No.1 People's Hospital of Nanjing Medical University, Huai'an, Jiangsu 223300, China.
Department of Gynecology, The Affiliated Huai'an No.1 People's Hospital of Nanjing Medical University, Huai'an, Jiangsu 223300, China.
J Gynecol Obstet Hum Reprod. 2023 Dec;52(10):102634. doi: 10.1016/j.jogoh.2023.102634. Epub 2023 Jul 26.
This study aimed to evaluate the efficacy of laparoscopic uterosacral ligament suspension (LUSLS) for pelvic organ prolapse (POP) using a meta-analysis method.
All articles about LUSLS published in English from Jan. 2010 to Jan. 2020 were retrieved using a computer from search engines, including PubMed, EMbase, Cochrane Library, CNKI, Wanfang, VIP, and Chinese Medical Journals. Meta-analysis was performed by two evaluators using RevMan 5.3 software according to the inclusion criteria.
A total of five studies were finally included, with 361 LUSLS cases and 361 control cases. LUSLS group showed a shorter operation duration (SMD-1.96; 95% CI = -3.90- -0.03; P = 0.05), more POP-quantification system (Q) (I) (SMD1.64; 95% CI = 1.05-2.56; P = 0.03), than the control group, with significant differences. There was no difference in the complication incidence, hospital stay, POP-Q>=II between the 2 groups (P > 0.05).
LUSLS was a safe and effective treatment for POP. Patients had higher postoperative satisfaction, shorter operation duration and satisfactory outcome. More high-quality randomized controlled trials are required in the future to make the results of the meta-analysis more accurate.
本研究旨在采用荟萃分析方法评估腹腔镜子宫骶韧带悬吊术（LUSLS）治疗盆腔器官脱垂（POP）的疗效。
通过计算机检索2010年1月至2020年1月期间以英文发表的所有关于LUSLS的文章，检索引擎包括PubMed、EMbase、Cochrane图书馆、中国知网、万方、维普和中国生物医学文献数据库。由两名评估者根据纳入标准使用RevMan 5.3软件进行荟萃分析。
最终共纳入5项研究，LUSLS组361例，对照组361例。LUSLS组手术时间短于对照组（标准化均数差[SMD]为-1.96；95%可信区间[CI]=-3.90至-0.03；P=0.05），盆腔器官脱垂定量系统（POP-Q）分期改善更明显（SMD为1.64；95%CI=1.05至2.56；P=0.03），差异有统计学意义。两组并发症发生率、住院时间、POP-Q≥Ⅱ期情况比较，差异无统计学意义（P>0.05）。
LUSLS是一种治疗POP安全有效的方法。患者术后满意度较高，手术时间短，效果满意。未来需要更多高质量的随机对照试验，以使荟萃分析结果更准确。
