多维度生物标志物在多系统萎缩中的应用：更新与未来方向。
Multidimensional biomarkers for multiple system atrophy: an update and future directions.
机构信息
Department of Neurology, Xiangya Hospital, Central South University, Changsha, 410008, China.
Key Laboratory of Hunan Province in Neurodegenerative Disorders, Central South University, Changsha, 410008, China.
出版信息
Transl Neurodegener. 2023 Jul 28;12(1):38. doi: 10.1186/s40035-023-00370-0.
Multiple system atrophy (MSA) is a fatal progressive neurodegenerative disease. Biomarkers are urgently required for MSA to improve the diagnostic and prognostic accuracy in clinic and facilitate the development and monitoring of disease-modifying therapies. In recent years, significant research efforts have been made in exploring multidimensional biomarkers for MSA. However, currently few biomarkers are available in clinic. In this review, we systematically summarize the latest advances in multidimensional biomarkers for MSA, including biomarkers in fluids, tissues and gut microbiota as well as imaging biomarkers. Future directions for exploration of novel biomarkers and promotion of implementation in clinic are also discussed.
多系统萎缩症（MSA）是一种致命的进行性神经退行性疾病。为了提高临床诊断和预后的准确性，促进疾病修饰治疗的发展和监测，目前迫切需要寻找 MSA 的生物标志物。近年来，人们在探索 MSA 的多维生物标志物方面做出了巨大的努力。然而，目前临床上可用的生物标志物很少。在这篇综述中，我们系统地总结了 MSA 的多维生物标志物的最新进展，包括体液、组织和肠道微生物群以及影像学生物标志物。此外，还讨论了探索新型生物标志物的未来方向以及促进其在临床上的应用。
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