Chen Ling, Li Guo-Hui, Chen Teng-Yu, Zheng Yun-Xue
College of Medical Technology, North Minzu University, Yinchuan 750021, China.
Acupuncture & Rehabilitation Center, Yinchuan Traditional Chinese Medicine Hospital, Yinchuan 750001, China.
Heliyon. 2023 Jul 3;9(7):e17910. doi: 10.1016/j.heliyon.2023.e17910. eCollection 2023 Jul.
Retroauricular injection is a local steroid hormone administration method commonly used to treat deafness or tinnitus. The acute stage of Bell's Palsy is an acute disease that requires steroid therapy. Retroauricular injection may replace oral administration of steroid hormones in the treatment of this disease as well as reduce the occurrence of adverse reactions.
This study included patients with Bell's Palsy within seven days of onset. A total of 120 patients were enrolled as the study subjects and randomly divided into two groups: the experimental group and the control group. Both groups received routine acupuncture treatment and took a traditional Chinese medicine decoction corresponding with the syndrome type. Methylprednisolone sodium succinate was injected into the bone surface of retroauricula in the experimental group, and prednisone acetate was orally administered in the control group. The main outcome indicators were the House-Brackmann (HB) grade, the facial disability index (FDI), and time of postauricular pain after one month of treatment.
There were no significant differences in the HB grade (2.00 ± 1.06 vs. 1.88 ± 1.06, P=), FDIP (97.25 ± 6.00 vs. 97.17 ± 7.39, P=), and FDIS (0.60 ± 3.02 vs. 1.33 ± 4.27, P=) at 30 days after treatment between the two groups (P > 0.05). Postauricular pain disappeared earlier in the experimental group (3.66 ± 1.67 days) than in the control group (6.31 ± 2.34); the difference was statistically significant (P ≤ 0.001). The adverse reaction rate was lower in the experimental group (15.00%) than in the control group (21.66%).
Although the dose of steroid hormone injected into the bone surface of retroauricula in the treatment of Bell's Palsy is lower than the administered dose of oral hormones, it has the same curative effect; however, it has a better effect regarding to the duration of postauricular pain and adverse reactions.
耳后注射是一种常用于治疗耳聋或耳鸣的局部甾体激素给药方法。贝尔面瘫急性期是一种需要甾体激素治疗的急性疾病。耳后注射在治疗该疾病时可能替代口服甾体激素，同时减少不良反应的发生。
本研究纳入发病7天内的贝尔面瘫患者。共纳入120例患者作为研究对象，随机分为两组：试验组和对照组。两组均接受常规针刺治疗，并服用与证型对应的中药汤剂。试验组将甲泼尼龙琥珀酸钠注射于耳后骨表面，对照组口服醋酸泼尼松。主要观察指标为治疗1个月后的House-Brackmann（HB）分级、面部残疾指数（FDI）及耳后疼痛时间。
两组治疗30天时，HB分级（2.00±1.06 vs. 1.88±1.06，P =）、FDIP（97.25±6.00 vs. 97.17±7.39，P =）和FDIS（0.60±3.02 vs. 1.33±4.27，P =）差异均无统计学意义（P＞0.05）。试验组耳后疼痛消失时间（3.66±1.67天）早于对照组（6.31±2.34天）；差异有统计学意义（P≤0.001）。试验组不良反应发生率（15.00%）低于对照组（21.66%）。
在贝尔面瘫治疗中，耳后骨表面注射甾体激素的剂量虽低于口服激素给药剂量，但疗效相同；然而，在耳后疼痛持续时间和不良反应方面效果更佳。
