Pasteurized improves glucose metabolism is linked with increased hypothalamic nitric oxide release.

BACKGROUND AND OBJECTIVE

Pasteurized cells have shown anti-diabetic effects in rodents and human. Although, its primary site of action consists in maintaining the gut barrier function, there are no study exploring if controls glycemia a gut to brain axis. Targeting the gut motility represents an alternative pathway to treat hyperglycemia. Here, we tested the impact of pasteurized on gut motility, gut-brain axis and glucose metabolism.

METHODS

We used mice fed a 45% high-fat (HFD) treated or not with pasteurized Muc during 12 weeks. We measured the effects of the treatment on body weight gain, glucose metabolism (insulin, glycemia, glucose tolerance), gut contraction and enteric neurotransmitter release, and hypothalamic nitric oxide (NO) release.

RESULTS

We show that pasteurized exerts positive effects on different metabolic parameters such as body weight, fat mass, insulin, glycemia and glucose tolerance. This could be explained by the ability of pasteurized supplementation to decrease duodenal contraction and to increase hypothalamic NO release in HFD mice.

CONCLUSION

We demonstrate a novel mode of action of pasteurized explaining its beneficial impact on the control of glycemia in a preclinical model of type 2 diabetes gut-brain axis signaling.