Kim You-Tae, Mills David A
Department of Food Science and Technology, University of California-Davis, Davis, CA USA.
Food Sci Biotechnol. 2024 Jun 27;33(9):2065-2080. doi: 10.1007/s10068-024-01620-1. eCollection 2024 Jul.
The human gut microbiome accompanies us from birth, and it is developed and matured by diet, lifestyle, and environmental factors. During aging, the bacterial composition evolves in reciprocal communication with the host's physiological properties. Many diseases are closely related to the gut microbiome, which means the modulation of the gut microbiome can promote the disease targeting remote organs. This review explores the intricate interaction between the gut microbiome and other organs, and their improvement from disease by prebiotics, probiotics, synbiotics, and postbiotics. Each section of the review is supported by clinical trials that substantiate the benefits of modulation the gut microbiome through dietary intervention for improving primary health outcomes across various axes with the gut. In conclusion, the review underscores the significant potential of targeting the gut microbiome for therapeutic and preventative interventions in a wide range of diseases, calling for further research to fully unlock the microbiome's capabilities in enhancing human health.
人类肠道微生物群从出生起就伴随着我们，并通过饮食、生活方式和环境因素发育成熟。在衰老过程中，细菌组成与宿主的生理特性相互作用而演变。许多疾病都与肠道微生物群密切相关，这意味着调节肠道微生物群可以促进针对远处器官的疾病治疗。这篇综述探讨了肠道微生物群与其他器官之间的复杂相互作用，以及通过益生元、益生菌、合生元和后生元对疾病的改善作用。综述的每个部分都有临床试验支持，这些试验证实了通过饮食干预调节肠道微生物群对改善肠道各个方面的主要健康结果的益处。总之，该综述强调了针对肠道微生物群进行广泛疾病的治疗和预防干预的巨大潜力，呼吁进一步研究以充分释放微生物群在促进人类健康方面的能力。
