葡萄糖刺激并由钙离子和肾上腺素介导的四膜虫中3',5'-环磷酸腺苷水平升高。
Increased levels of adenosine 3',5'-cyclic monophosphate in Tetrahymena stimulated by glucose and mediated by Ca2+ and epinephrine.
作者信息
Nandini-Kishore S G, Thompson G A
出版信息
Proc Natl Acad Sci U S A. 1979 Jun;76(6):2708-11. doi: 10.1073/pnas.76.6.2708.
Abstract
Stationary phase Tetrahymena cells exposed to 0.5-1% glucose experience an 8-fold increase in intracellular cyclic AMP within 1 hr. The increase follows an enhanced uptake of Ca2+ triggered by the glucose addition. Inhibiting the Ca2+ influx with ethylene glycol bis(beta-aminoethyl ether)-N,N,N',N'-tetraacetic acid blocks the increase in cyclic AMP, but the block can be reversed by the addition of epinephrine. Both this epinephrine effect and the glucose-induced increase in cyclic AMP are counteracted by the beta-adrenergic inhibitor dichloroisoproterenol.
摘要
静止期的四膜虫细胞暴露于0.5 - 1%的葡萄糖中，1小时内细胞内的环磷酸腺苷（cAMP）增加8倍。这种增加是由添加葡萄糖引发的钙离子（Ca2+）摄取增强所导致的。用乙二醇双（β - 氨基乙基醚）- N,N,N',N'-四乙酸抑制Ca2+内流可阻断环磷酸腺苷的增加，但添加肾上腺素可逆转这种阻断。β - 肾上腺素能抑制剂二氯异丙肾上腺素可抵消这种肾上腺素效应以及葡萄糖诱导的环磷酸腺苷增加。
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