3',5'-单磷酸腺苷与梨形四膜虫生长和代谢的关系。
Relationship of adenosine 3',5'-monophosphate to growth and metabolism of Tetrahymena pyriformis.
作者信息
Voichick J, Elson C, Granner D, Shrago E
出版信息
J Bacteriol. 1973 Jul;115(1):68-72. doi: 10.1128/jb.115.1.68-72.1973.
Abstract
The concentration of adenosine 3',5'-monophosphate (cyclic AMP) and the activity of adenylate cyclase were determined for the first time in conjuncation with cyclic 3',5'-nucleotide phosphodiesterase (phosphodiesterase) during the growth cycle of Tetrahymena pyriformis. High levels of cyclic AMP observed during early exponential and late stationary phases were associated with elevated adenylate cyclase and decreased phosphodiesterase activities. Adenylate cyclase and cyclic AMP were decreased and phosphodiesterase was increased in cells grown in glucose-supplemented medium. In contrast to findings in mammalian liver, cyclic AMP was decreased during active gluconeogenesis in Tetrahymena. This suggests a different modulation of carbohydrate metabolism in the two species. The results illustrate that both the content of cyclic AMP and its action as a regulatory agent in Tetrahymena are uniquely suited to the metabolism of this organism.
摘要
在梨形四膜虫的生长周期中，首次结合环3',5'-核苷酸磷酸二酯酶（磷酸二酯酶）测定了3',5'-环磷酸腺苷（环磷酸腺苷）的浓度和腺苷酸环化酶的活性。在指数生长期早期和稳定期后期观察到的高水平环磷酸腺苷与腺苷酸环化酶活性升高和磷酸二酯酶活性降低有关。在补充葡萄糖的培养基中生长的细胞中，腺苷酸环化酶和环磷酸腺苷减少，而磷酸二酯酶增加。与哺乳动物肝脏中的发现相反，在梨形四膜虫活跃的糖异生过程中环磷酸腺苷减少。这表明这两个物种中碳水化合物代谢的调节方式不同。结果表明，环磷酸腺苷的含量及其作为梨形四膜虫调节因子的作用都非常适合该生物体的代谢。
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