Diness V, Nielsen J I, Pedersen P C, Wolffbrandt K H, Ostergaard P B
Thromb Haemost. 1986 Jun 30;55(3):410-4.
The antithrombotic effects after intravenous administration of a low molecular weight heparin (LHN-1) and conventional heparin were compared in a rabbit model of experimental thrombosis, where thrombus formation was induced by a combination of endothelial damage and stasis. Both compounds were able to prevent thrombosis completely. However, LHN-1 was significantly less potent than conventional heparin, the ratio between doses with the same antithrombotic effect being 2.4:1 on a weight basis. Bleeding times after administration of LHN-1 and conventional heparin were determined by tail transsection in anaesthetized rats and by template bleeding in the ear of conscious pigs. Given intravenously at a dose ratio of 2.4:1 (w/w), LHN-1 affected APTT less than conventional heparin, whereas the effects on haemostasis were not significantly different. In conclusion, it was found that after intravenous administration LHN-1 prevented experimental thrombosis as effectively as conventional heparin. However, the correlation between antithrombotic and haemorrhagic effects of LHN-1 was the same as that of conventional heparin. The corresponding relation in man remains to be determined.
在由内皮损伤和血流淤滞共同诱导血栓形成的兔实验性血栓模型中，比较了静脉注射低分子量肝素（LHN-1）和传统肝素后的抗血栓作用。两种化合物均能完全预防血栓形成。然而，LHN-1的效力明显低于传统肝素，具有相同抗血栓作用的剂量比按重量计为2.4:1。通过在麻醉大鼠中进行尾部横切以及在清醒猪的耳部进行模板出血来测定注射LHN-1和传统肝素后的出血时间。以2.4:1（w/w）的剂量比静脉给药时，LHN-1对活化部分凝血活酶时间（APTT）的影响小于传统肝素，而对止血的影响无显著差异。总之，发现静脉注射后LHN-1预防实验性血栓形成的效果与传统肝素相同。然而，LHN-1抗血栓和出血作用之间的相关性与传统肝素相同。在人体中的相应关系仍有待确定。
