Bergqvist D, Nilsson B
Department of Surgery, University of Lund, General Hospital, Malmö, Sweden.
Thromb Haemost. 1987 Oct 28;58(3):893-5.
The influence of low molecular weight heparin in combination with dihydroergotamine (DHE) on thrombus formation and primary haemostasis was investigated in rabbit models. Conventional heparin in the dose of 60 units anti Xa activity/kg b. w. effectively prevented thrombus formation but the same dose of a low molecular weight fragment only gave a marginal decrease of the frequency of thrombosis. The thrombus weight was, however, significantly reduced. Doubling the dose of the heparin fragment totally abolished thrombus formation as did the combination of 60 units with DHE. With DHE it was also possible to diminish the low molecular weight heparin dose to 30 units with a good prophylactic effect. There was a small but significant increase of haemostatic plug formation time in all treatment groups except the one with low molecular weight heparin fragment 30 units anti Xa activity combined with DHE. Thus, by combining low molecular weight heparin in a low dose with DHE it is possible to prevent thrombus formation without influencing primary haemostasis in rabbits.
在兔模型中研究了低分子量肝素联合双氢麦角胺（DHE）对血栓形成和初级止血的影响。剂量为60抗Xa活性单位/千克体重的常规肝素能有效预防血栓形成，但相同剂量的低分子量片段仅使血栓形成频率略有降低。然而，血栓重量显著减轻。将肝素片段剂量加倍可完全消除血栓形成，60单位肝素与DHE联合使用也有同样效果。使用DHE时，将低分子量肝素剂量减至30单位也具有良好的预防效果。除了低分子量肝素片段30抗Xa活性单位与DHE联合使用的组外，所有治疗组的止血栓形成时间均有小幅但显著的增加。因此，在兔中，低剂量低分子量肝素与DHE联合使用可预防血栓形成而不影响初级止血。
