Tasmin Saira, Aschebrook-Kilfoy Briseis, Hedeker Donald, Gopalakrishnan Rajan, Stepniak Elizabeth, Kibriya Muhammad G, Young Michael T, Kaufman Joel D, Ahsan Habibul
University of Chicago.
University of Washington.
Res Sq. 2023 Jul 21:rs.3.rs-3171526. doi: 10.21203/rs.3.rs-3171526/v1.
To examine whether air pollution exposure is associated with central hemodynamic and brachial artery stiffness parameters.
We assessed central hemodynamic parameters, brachial artery stiffness measures [including brachial artery distensibility (BAD), compliance (BAC), and resistance (BAR)] using waveform analysis of the arterial pressure signals obtained from a standard cuff sphygmomanometer (DynaPulse2000A, San Diego, CA). The long-term exposures to particles with an aerodynamic diameter < 2.5μm (PM2.5) and nitrogen dioxide (NO2) for the 3-year periods prior to enrollment were estimated at residential addresses using fine-scale intra-urban spatiotemporal models. Linear mixed models adjusted for potential confounders were used to examine associations between air pollution exposures and health outcomes.
The cross-sectional study included 2,387 Chicago residents (76% African Americans) enrolled in the ChicagO Multiethnic Prevention And Surveillance Study (COMPASS) during 2013-2018 with validated address information, PM2.5 or NO2, key covariates, and hemodynamics measurements. We observed long-term concentrations of PM2.5 and NO2 to be positively associated with central systolic, pulse pressure and BAR, and negatively associated with BAD, and BAC after adjusting for relevant covariates. A 1-μg/m increment in preceding 3-year exposures to PM2.5 was associated with 1.8 mmHg higher central systolic (95% CI: 0.98, 4.16), 1.0 mmHg higher central pulse pressure (95% CI: 0.42, 2.87), a 0.56%mmHg lower BAD (95% CI: -0.81, -0.30), and a 0.009 mL/mmHg lower BAC (95% CI: -0.01, -0.01).
This population-based study provides evidence that long-term exposures to PM2.5 and NO2 is related to central BP and arterial stiffness parameters, especially among African Americans.
研究空气污染暴露是否与中心血流动力学及肱动脉僵硬度参数相关。
我们使用从标准袖带血压计（DynaPulse2000A，加利福尼亚州圣地亚哥）获取的动脉压力信号的波形分析，评估中心血流动力学参数、肱动脉僵硬度指标[包括肱动脉扩张性（BAD）、顺应性（BAC）和阻力（BAR）]。在入组前3年期间，使用精细尺度的城市内部时空模型，根据居住地址估算对空气动力学直径<2.5μm的颗粒物（PM2.5）和二氧化氮（NO2）的长期暴露情况。采用针对潜在混杂因素进行调整的线性混合模型，研究空气污染暴露与健康结局之间的关联。
这项横断面研究纳入了2387名芝加哥居民（76%为非裔美国人），他们在2013年至2018年期间参加了芝加哥多民族预防与监测研究（COMPASS），并拥有经过验证的地址信息、PM2.5或NO2、关键协变量以及血流动力学测量数据。在调整相关协变量后，我们观察到PM2.5和NO2的长期浓度与中心收缩压、脉压和BAR呈正相关，与BAD和BAC呈负相关。在之前3年中，PM2.5暴露每增加1μg/m³，中心收缩压升高1.8 mmHg（95%置信区间：0.98，4.16），中心脉压升高1.0 mmHg（95%置信区间：0.42，2.87），BAD降低0.56%mmHg（95%置信区间：-0.81，-0.30），BAC降低0.009 mL/mmHg（95%置信区间：-0.01，-0.01）。
这项基于人群的研究提供了证据，表明长期暴露于PM2.5和NO2与中心血压及动脉僵硬度参数有关，尤其是在非裔美国人中。
