Section of Dermatology, Department of Health Sciences, University of Florence, Florence, Italy.
Rare Skin Diseases Unit, Department of Health Sciences, Azienda USL Toscana Centro (ERN-SKIN), University of Florence, Florence, Italy.
Front Immunol. 2023 Jul 12;14:1222459. doi: 10.3389/fimmu.2023.1222459. eCollection 2023.
It is well known that viral infections play a relevant role in inducing or protecting from autoimmune diseases, thus representing a major environmental factor in the disruption of the immune system in genetically susceptible individuals. Since the beginning of the Covid-19 pandemic a great number of clinical and epidemiological studies have demonstrated that SARS-CoV-2 infection is no exception to the rule by interfering on many different levels in the normal functioning of our immune system. Even though a growing number of case series and case reports has been cited in the literature linking the infection to the new onset of autoimmune diseases, to date very little has been reported concerning a possible correlation between the virus and the clinical resolution of any kind of autoimmune pathology. Here we describe an interesting case of abrupt and unexpected resolution of Lichen planus pemphigoides mucocutaneous lesions in a fully vaccinated patient after a mildly symptomatic SARS-CoV-2 respiratory infection and we speculate on the possible underlying mechanisms correlating the two events.
众所周知，病毒感染在诱导或保护自身免疫性疾病方面发挥着重要作用，因此是导致遗传易感个体免疫系统紊乱的主要环境因素。自新冠疫情大流行开始以来，大量的临床和流行病学研究表明，SARS-CoV-2 感染也不例外，它在多个层面上干扰了我们免疫系统的正常功能。尽管文献中已经引用了越来越多的病例系列和病例报告，将感染与自身免疫性疾病的新发病例联系起来，但迄今为止，关于病毒与任何类型的自身免疫性病理的临床缓解之间是否存在关联，报道得非常少。在这里，我们描述了一例有趣的病例，在一名完全接种疫苗的患者中，在轻度有症状的 SARS-CoV-2 呼吸道感染后，天疱疮样扁平苔藓的粘膜皮肤病变突然且意外地消退，我们推测了这两个事件之间可能存在的相关机制。
