类天疱疮样扁平苔藓：病例报告及免疫荧光和免疫电镜研究结果

Lichen planus pemphigoides: case report and results of immunofluorescence and immunoelectron microscopic study.

作者信息

Okochi H, Nashiro K, Tsuchida T, Seki Y, Tamaki K

机构信息

Department of Dermatology, Faculty of Medicine, Tokyo University Branch Hospital, University of Tokyo, Japan.

出版信息

J Am Acad Dermatol. 1990 Apr;22(4):626-31. doi: 10.1016/0190-9622(90)70085-v.

DOI:10.1016/0190-9622(90)70085-v

PMID:2180994

Abstract

A Japanese woman with lichen planus pemphigoides is reported. Immunologic characteristics of lichen planus pemphigoides antigen in the patient were investigated by indirect immunofluorescence and compared with those of bullous pemphigoid antigen or epidermolysis bullosa acquisita antigen. Ultrastructural localization of lichen planus pemphigoides antigen was studied with the use of immunoelectron microscopic techniques. Lichen planus pemphigoides antigen showed localization similar to that of bullous pemphigoid antigen but different from that of epidermolysis bullosa acquisita antigen. The antigenic stability of lichen planus pemphigoides antigen was different from that of bullous pemphigoid antigen or epidermolysis bullosa acquisita antigen. Thus this study demonstrates that lichen planus pemphigoides antigen is different from bullous pemphigoid antigen.

摘要

报告了一名患有类天疱疮样扁平苔藓的日本女性。通过间接免疫荧光法研究了该患者类天疱疮样扁平苔藓抗原的免疫学特征，并与大疱性类天疱疮抗原或获得性大疱性表皮松解症抗原的特征进行了比较。利用免疫电子显微镜技术研究了类天疱疮样扁平苔藓抗原的超微结构定位。类天疱疮样扁平苔藓抗原的定位与大疱性类天疱疮抗原相似，但与获得性大疱性表皮松解症抗原不同。类天疱疮样扁平苔藓抗原的抗原稳定性与大疱性类天疱疮抗原或获得性大疱性表皮松解症抗原不同。因此，本研究表明类天疱疮样扁平苔藓抗原与大疱性类天疱疮抗原不同。