Shine Billie, Alvarez Moreno Juan Carlos, Coblens Orly, Qiu Suimin, Clement Cecilia G
Pathology, University of Texas Medical Branch, Galveston, USA.
Otolaryngology, University of Texas Medical Branch, Galveston, USA.
Cureus. 2023 Jun 26;15(6):e40990. doi: 10.7759/cureus.40990. eCollection 2023 Jun.
Sarcomatoid carcinoma (SC) of the larynx is an uncommon subtype of squamous cell carcinoma which shows both squamous carcinoma and a sarcomatous component, including heterologous elements. The presence of rhabdomyosarcomatous elements in the larynx is extremely rare. Diagnosis of SC can be particularly challenging when the malignant epithelial component is not evident. We present a case of SC in a 72-year-old man with a superficial exophytic mass in the vocal cord initially misdiagnosed as rhabdomyosarcoma due to a predominant spindle cell component with rhabdomyoblastic features by morphology and immunohistochemistry. This case report aims to increase awareness that a rhabdomyoblastic heterologous component can be present in SC of the larynx and to consider this diagnosis in a mucosal exophytic malignant spindle cell neoplasm, even in the absence of epithelial differentiation.
喉肉瘤样癌（SC）是鳞状细胞癌的一种罕见亚型，兼具鳞状细胞癌和肉瘤成分，包括异源性成分。喉内出现横纹肌肉瘤成分极为罕见。当恶性上皮成分不明显时，SC的诊断可能极具挑战性。我们报告一例72岁男性的SC病例，其声带浅表外生性肿物最初因形态学和免疫组织化学显示主要为具有横纹肌母细胞特征的梭形细胞成分而被误诊为横纹肌肉瘤。本病例报告旨在提高人们对喉SC中可出现横纹肌母细胞异源性成分的认识，并提示即使在无上皮分化的情况下，对于黏膜外生性恶性梭形细胞瘤也应考虑这一诊断。
