Gudi Sai Krishna, Eltonsy Sherif, Delaney Joseph, Osiowy Carla, Taylor Carole, Kaita Kelly, Alessi-Severini Silvia
College of Pharmacy, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada.
Department of Epidemiology, University of Washington, Seattle, Washington, USA.
Can Liver J. 2023 Jul 26;6(2):249-260. doi: 10.3138/canlivj-2022-0030. eCollection 2023 Jul.
Hepatitis C virus (HCV) infection is a major cause of liver-related morbidity and mortality worldwide. Epidemiological data of HCV infection in the Canadian province of Manitoba are limited.
A population-based retrospective study was conducted using data from the Manitoba Centre for Health Policy repository. Using the test results provided by the Cadham provincial laboratory, individuals in Manitoba with a diagnosis of HCV infection were identified. Annual prevalence and incidence rates (crude and standardized) were calculated for the overall population and stratified by sex, regional health authority (RHA), residence area, income quintile, and special population groups (children, older adults, and pregnant persons).
A total of 8,721 HCV cases were diagnosed between 1998 and 2018 in Manitoba. Overall crude HCV incidence and prevalence were estimated as 0.03% and 0.37% during the study period, respectively. No significant change was observed in the standardized HCV incidence rate (per 100,000) during the study period (54.3 in 1998 and 54.8 in 2018). However, the standardized HCV prevalence (per 100,000) increased from 52.5 (95% CI 39.2-68.7) in 1998 to 655.2 (95% CI 605.9-707.3) in 2018. An overall average incidence rate based on sex, RHA, region, income, and special population groups was observed to be higher in males (40.1), Winnipeg RHA (42.7), urban region (42.3), low-income quintiles (78.5), and pregnant persons (94.3), respectively.
Although incidence rates of HCV infection in Manitoba appeared to have initially declined, rates showed an upward trend by the end of the study period while prevalence increased steadily.
丙型肝炎病毒（HCV）感染是全球肝脏相关发病和死亡的主要原因。加拿大曼尼托巴省HCV感染的流行病学数据有限。
利用曼尼托巴省卫生政策中心数据库的数据进行了一项基于人群的回顾性研究。通过Cadham省级实验室提供的检测结果，确定了曼尼托巴省诊断为HCV感染的个体。计算了总体人群以及按性别、地区卫生当局（RHA）、居住地区、收入五分位数和特殊人群组（儿童、老年人和孕妇）分层的年度患病率和发病率（粗率和标准化率）。
1998年至2018年期间，曼尼托巴省共诊断出8721例HCV病例。研究期间，总体HCV粗发病率和患病率分别估计为0.03%和0.37%。研究期间标准化HCV发病率（每10万人）未观察到显著变化（1998年为54.3，2018年为54.8）。然而，标准化HCV患病率（每10万人）从1998年的52.5（95%CI 39.2 - 68.7）增至2018年的655.2（95%CI 605.9 - 707.3）。基于性别、RHA、地区、收入和特殊人群组的总体平均发病率在男性（40.1）、温尼伯RHA（42.7）、城市地区（42.3）、低收入五分位数（78.5）和孕妇（94.3）中分别较高。
尽管曼尼托巴省HCV感染发病率最初似乎有所下降，但在研究期末呈上升趋势，而患病率稳步上升。
