Department of Orthodontics, School of Dentistry, National and Kapodistrian University of Athens, Greece.
Department of Orthodontics and Dentofacial Orthopedics, Dental School/Medical Faculty, University of Bern, Switzerland.
Eur J Orthod. 2023 Nov 30;45(6):781-787. doi: 10.1093/ejo/cjad036.
BACKGROUND/OBJECTIVES: The aim of this trial was to investigate the effect of mastic mouthwash on halitosis using as a proxy the levels of the Volatile Sulfur Compounds (VSCs), and the effect on plaque and gingival indices in adolescents undergoing orthodontic treatment with fixed conventional labial appliances.
SUBJECTS/METHODS: The study was a double-blinded, placebo-controlled, parallel-group, randomized clinical trial. Thirty patients with fixed orthodontic appliances were randomly allocated at a 1:1 ratio, to either the mastic-mouthwash or the placebo-mouthwash group. Eligibility criteria included ages between 13 and 18, active orthodontic treatment with fixed appliances, good general health, and total initial VSCs levels above 150 ppb. The primary outcome was the objective hydrogen sulfide (H2S) level, measured with the Oral ChromaTM device. The secondary outcomes were (1.) the methyl-mercaptan (CH3SH) and (2.) dimethyl sulfide [(CH3)2S] levels, measured with the same device, (3.) the subjective perception of the own malodour via questionnaires, and (4.) the oral hygiene assessed with the use of the Modified Silness and Löe Plaque Index (PI-M) and the Silness and Löe Gingival Index (GI) at baseline (T0) and after 2 weeks (T1). Stratified randomization by gender was used, and allocation was concealed with opaque numbered sealed envelopes.
H2S level dropped from 221.00 ppb (T0) to 125.00 ppb (T1), and the difference between treatment groups was statistically significant in favour of the mastic group (coef: 72.34, 95% CI: 8.48, 136.27, P = 0.03). The levels of the other VSCs, the subjective measurements of oral malodour, and the oral hygiene indices did not differ between treatment arms.
The objective organoleptic assessment by a calibrated examiner was not performed.
CONCLUSIONS/IMPLICATIONS: Mastic mouthwashes could be an alternative treatment for adolescent patients suffering from halitosis during orthodontic treatment with fixed appliances.
The trial was registered at ClinicalTrials.gov (identifier: NCT05647369).
背景/目的：本试验旨在通过测量挥发性硫化合物（VSCs）的水平，来研究乳香漱口水对口臭的影响，并评估其对接受固定传统唇侧矫治器正畸治疗的青少年的菌斑和牙龈指数的影响。
受试者/方法：这是一项双盲、安慰剂对照、平行组、随机临床试验。将 30 名接受固定正畸治疗的患者按 1:1 的比例随机分为乳香漱口水组或安慰剂漱口水组。纳入标准包括年龄在 13 至 18 岁之间、接受固定矫治器的积极正畸治疗、身体健康状况良好、初始总 VSCs 水平高于 150 ppb。主要结局指标是使用 Oral ChromaTM 设备测量的客观硫化氢（H2S）水平。次要结局指标包括：（1）使用相同设备测量的甲基硫醇（CH3SH）和（2）二甲硫醚[(CH3)2S]水平；（3）通过问卷调查评估自身口臭的主观感知；（4）使用改良 Silness 和 Löe 菌斑指数（PI-M）和 Silness 和 Löe 牙龈指数（GI）评估口腔卫生状况，分别在基线（T0）和 2 周后（T1）进行评估。采用按性别分层的随机化，通过不透明编号密封信封进行分配隐藏。
H2S 水平从 221.00 ppb（T0）降至 125.00 ppb（T1），且乳香组的治疗效果优于安慰剂组，差异具有统计学意义（系数：72.34，95%CI：8.48，136.27，P=0.03）。其他 VSCs 水平、口臭的主观测量和口腔卫生指数在治疗组之间无差异。
未进行由经过校准的检查者进行的客观感官评估。
结论/意义：乳香漱口水可能是一种治疗接受固定矫治器正畸治疗的青少年口臭的替代疗法。
该试验在 ClinicalTrials.gov 注册（标识符：NCT05647369）。
