Department of Periodontology, Operative and Preventive Dentistry, University of Bonn, Germany.
J Breath Res. 2019 Mar 1;13(2):026005. doi: 10.1088/1752-7163/aaf401.
This randomized controlled cross-over-design-study investigated short-term effects on oral malodour of a zinc-lactate-containing mouthwash.
Sixteen subjects (18-65 years) with an organoleptic score (OLS) ≥2 were included. Following rinses were used: (A) a zinc-lactate-containing mouthwash (10 ml/30 s); (B) a zinc-lactate-containing mouthwash (15 ml/60 s); (C) a rinse without zinc-lactate (3 droplets/10 ml tap water/30 s) and (D) tap water (10 ml/30 s). Each formulation was evaluated by two blinded examiners comparing OLS and three volatile-sulphur-compounds (VSC; HS (hydrogen sulphide), CHSH (methyl mercaptan) and (CH)S (dimethyl sulphide)) before, 1 and 3 h after rinsing. Subject's perception was investigated with a visual-analogue-scale. Linear mixed models were used to compare all parameters simultaneously with respect to the four treatment groups with a significance level α < 0.05.
OLS was significantly reduced by A and B compared to C and D after 3 h (p < 0.006). The sum of the 3 VSCs as well as HS alone were significantly reduced by rinses A and B after 1 and 3 h compared to rinses C and D (p < 0.05). Significant differences were found between the four rinses for 'Taste' (p = 0.003), for 'Change of mouth feeling' (p = 0.001), for 'Feeling of freshness' (p = 0.002) and for 'Effectiveness' (p = 0.002) in favour of A & B.
A zinc-lactate-containing mouthwash reduced OLS and VSC over a period of 3 h with favourable patient reported outcomes.
本随机对照交叉设计研究旨在探讨含乳酸锌的漱口水对口腔异味的短期影响。
纳入了 16 名（18-65 岁）口腔异味评分（OLS）≥2 的受试者。使用以下漱口液：（A）含乳酸锌的漱口水（10 毫升/30 秒）；（B）含乳酸锌的漱口水（15 毫升/60 秒）；（C）不含乳酸锌的漱口液（3 滴/10 毫升自来水/30 秒）和（D）自来水（10 毫升/30 秒）。在漱口前、漱口后 1 小时和 3 小时，由两名盲审员使用 OLS 和三种挥发性硫化合物（VSC；HS（硫化氢）、CHSH（甲硫醇）和（CH）S（二甲硫））进行评估。通过视觉模拟量表调查了受试者的感知。使用线性混合模型同时比较了所有参数，以四个治疗组为对象，显著性水平为 α<0.05。
与 C 和 D 相比，A 和 B 在漱口后 3 小时时 OLS 明显降低（p<0.006）。与 C 和 D 相比，A 和 B 在漱口后 1 小时和 3 小时时，三种 VSC 之和以及 HS 单独均明显降低（p<0.05）。在“口感”（p=0.003）、“口腔感觉变化”（p=0.001）、“清新感”（p=0.002）和“效果”（p=0.002）方面，四种漱口液之间存在显著差异，A 和 B 更受青睐。
含乳酸锌的漱口水在 3 小时内可降低 OLS 和 VSC，且患者报告的结果良好。
