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[从患有实验性肿瘤的动物血液中分离出的红细胞对培养的肿瘤细胞增殖活性的影响]

[Effect of erythrocytes isolated from the blood of animals with experimental tumors on the proliferative activity of cultured tumor cells].

作者信息

Sopotsinskaia E B, Fadeev V A

出版信息

Tsitologiia. 1986 Jun;28(6):642-6.

PMID:3750414
Abstract

It has been established that erythrocytes taken from blood of mice with experimental tumors being in the active phase of growth, or of mice with a recidivation of the primary tumor intensify proliferative processes in the culture of tumor cells. Erythrocytes from animals with tumors being in the stationary phase of growth did not reveal such a capacity. The authors connect such an effect with the erythrocyte transport function due to which they can store up those factors excreted by tumors which stimulate proliferation. It is supposed that the test defining the peculiarities of the effect of erythrocytes on the proliferative capacity of tumor cells in the tissue culture can be used for the judgement about an individual activity of the growth of primary tumors as well as for the diagnostics of recidivation of tumor growth.

摘要

已经确定,从处于生长活跃期的实验性肿瘤小鼠血液中采集的红细胞,或从原发性肿瘤复发的小鼠血液中采集的红细胞,会增强肿瘤细胞培养中的增殖过程。处于生长静止期的肿瘤动物的红细胞没有显示出这种能力。作者将这种效应与红细胞的运输功能联系起来,由于这种功能,它们可以储存肿瘤分泌的那些刺激增殖的因子。据推测,确定红细胞对组织培养中肿瘤细胞增殖能力影响特性的试验,可用于判断原发性肿瘤生长的个体活性以及肿瘤生长复发的诊断。

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