Jeong Myeongguk, Ju Yeongdon, Kwon Hyeokjin, Kim Yeeun, Hyun Kyung-Yae, Choi Go-Eun
Department of Biomedical Laboratory Science, College of Health Sciences, Catholic University of Pusan, Busan 46252, Republic of Korea.
Medical Science Research Center, Pusan National University, Yangsan 50612, Republic of Korea.
Curr Issues Mol Biol. 2023 Jul 16;45(7):5950-5966. doi: 10.3390/cimb45070376.
Nakai offers a reliable and efficient source of antioxidants that can help alleviate adverse skin reactions triggered by air pollutants. Air pollutants, such as particulate matter (PM), have the ability to infiltrate the skin and contribute to the higher occurrence of cardiovascular, cerebrovascular, and respiratory ailments. Individuals with compromised skin barriers are particularly susceptible to the impact of PM since it can be absorbed more readily through the skin. This study investigated the impact of protocatechuic acid and syringin, obtained from the n-BuOH extract of Nakai, on the release of PGE and PGD induced by PM. Additionally, it examined the gene expression of the synthesis of PGE and PGD in human keratinocytes. The findings of this research highlight the potential of utilizing safe and efficient plant-derived antioxidants in dermatological and cosmetic applications to mitigate the negative skin reactions caused by exposure to air pollution.
中井提供了一种可靠且高效的抗氧化剂来源，有助于减轻由空气污染物引发的不良皮肤反应。空气污染物，如颗粒物（PM），能够渗透到皮肤中，并导致心血管、脑血管和呼吸系统疾病的更高发生率。皮肤屏障受损的个体特别容易受到PM的影响，因为它可以更容易地通过皮肤被吸收。本研究调查了从日本紫珠正丁醇提取物中获得的原儿茶酸和紫丁香苷对PM诱导的PGE和PGD释放的影响。此外，还检测了人角质形成细胞中PGE和PGD合成的基因表达。这项研究的结果突出了在皮肤病学和化妆品应用中利用安全高效的植物源抗氧化剂来减轻因接触空气污染而引起的负面皮肤反应的潜力。
