Quazi Mohzibudin Z, Hwang Jimin, Song Youngseo, Park Nokyoung
Department of Chemistry and the Natural Science Research Institute, Myongji University, 116 Myongji-ro, Yongin-si 17058, Gyeonggi-do, Republic of Korea.
Gels. 2023 Jul 4;9(7):545. doi: 10.3390/gels9070545.
Nanotechnology and polymer engineering are navigating toward new developments to control and overcome complex problems. In the last few decades, polymer engineering has received researchers' attention and similarly, polymeric network-engineered structures have been vastly studied. Prior to therapeutic application, early and rapid detection analyses are critical. Therefore, developing hydrogel-based sensors to manage the acute expression of diseases and malignancies to devise therapeutic approaches demands advanced nanoengineering. However, nano-therapeutics have emerged as an alternative approach to tackling strenuous diseases. Similarly, sensing applications for multiple kinds of analytes in water-based environments and other media are gaining wide interest. It has also been observed that these functional roles can be used as alternative approaches to the detection of a wide range of biomolecules and pathogenic proteins. Moreover, hydrogels have emerged as a three-dimensional (3D) polymeric network that consists of hydrophilic natural or synthetic polymers with multidimensional dynamics. The resemblance of hydrogels to tissue structure makes them more unique to study inquisitively. Preceding studies have shown a vast spectrum of synthetic and natural polymer applications in the field of biotechnology and molecular diagnostics. This review explores recent studies on synthetic and natural polymers engineered hydrogel-based biosensors and their applications in multipurpose diagnostics and therapeutics. We review the latest studies on hydrogel-engineered biosensors, exclusively DNA-based and DNA hydrogel-fabricated biosensors.
纳米技术和聚合物工程正在朝着新的发展方向前进，以控制和克服复杂问题。在过去几十年中，聚合物工程受到了研究人员的关注，同样，聚合物网络工程结构也得到了广泛研究。在治疗应用之前，早期和快速检测分析至关重要。因此，开发基于水凝胶的传感器来管理疾病和恶性肿瘤的急性表现以设计治疗方法需要先进的纳米工程技术。然而，纳米治疗已成为治疗疑难疾病的一种替代方法。同样，在水基环境和其他介质中对多种分析物的传感应用也引起了广泛关注。还观察到，这些功能作用可作为检测多种生物分子和致病蛋白的替代方法。此外，水凝胶已成为一种三维（3D）聚合物网络，由具有多维动力学的亲水性天然或合成聚合物组成。水凝胶与组织结构的相似性使其更具独特性，值得深入研究。先前的研究表明，合成和天然聚合物在生物技术和分子诊断领域有广泛应用。本综述探讨了关于合成和天然聚合物工程化水凝胶基生物传感器及其在多用途诊断和治疗中的应用的最新研究。我们回顾了水凝胶工程化生物传感器的最新研究，特别是基于DNA和DNA水凝胶制造的生物传感器。
