Saeed Sana, Barkat Kashif, Ashraf Muhammad Umer, Shabbir Maryam, Anjum Irfan, Badshah Syed Faisal, Aamir Muhammad, Malik Nadia Shamshad, Tariq Akash, Ullah Riaz
Faculty of Pharmacy, The University of Lahore, Lahore 54000, Pakistan.
Department of Basic Medical Sciences, Shifa College of Pharmaceutical Sciences, Shifa Tameer-e-Millat University, Islamabad 44000, Pakistan.
Gels. 2023 Jul 12;9(7):567. doi: 10.3390/gels9070567.
A hydrogel topical patch of neomycin was developed by using sodium alginate (SA) and hydroxyethylcellulose (HEC) as polymers. Free radical polymerization in an aqueous medium was initiated by using acrylic acid (AA) and N,N'-methylenebisacrylamide (MBA). Prepared hydrogels were characterized for pH sensitivity and sol-gel analysis. In addition, the effect of reactant contents on the developed formulation was evaluated by swelling behavior. SEM assay showed the rough structure of the hydrogel-based polymeric matrix, which directly enhances the ability to uptake fluid. FTIR spectra revealed the formation of a new polymeric network between reactant contents. TGA and DSC verified that fabricated polymeric patches were more thermodynamically stable than pure components. Gel fractions increased with increases in polymer, monomer, and cross-linker contents. The swelling study showed the pH-dependent swelling behavior of patches at pH 5.5, 6.5, and 7.4. The release pattern of the drug followed zero-order kinetics, with diffusion-controlled drug release patterns according to the Korsmeyer-Peppas (KP) model. Ex vivo studies across excised rabbit skin verified the drug retention in the skin layers. The hydrogel patch effectively healed the wounds produced on the rabbit skin, whereas the formulation showed no sign of irritation on intact skin. Therefore, neomycin hydrogel patches can be a potential candidate for controlled delivery for efficient wound healing.
以海藻酸钠（SA）和羟乙基纤维素（HEC）作为聚合物，制备了一种新霉素水凝胶局部贴剂。使用丙烯酸（AA）和N，N'-亚甲基双丙烯酰胺（MBA）在水介质中引发自由基聚合反应。对制备的水凝胶进行pH敏感性和溶胶-凝胶分析表征。此外，通过溶胀行为评估反应物含量对所开发制剂的影响。扫描电子显微镜（SEM）分析显示基于水凝胶的聚合物基质结构粗糙，这直接增强了其吸收液体的能力。傅里叶变换红外光谱（FTIR）显示反应物之间形成了新的聚合物网络。热重分析（TGA）和差示扫描量热法（DSC）证实，制备的聚合物贴剂比纯组分在热力学上更稳定。凝胶分数随聚合物、单体和交联剂含量的增加而增加。溶胀研究表明，贴剂在pH 5.5、6.5和7.4时具有pH依赖性溶胀行为。药物释放模式符合零级动力学，根据Korsmeyer-Peppas（KP）模型呈现扩散控制的药物释放模式。对切除的兔皮进行的体外研究证实了药物在皮肤层中的滞留情况。水凝胶贴剂有效地治愈了兔皮上产生的伤口，而该制剂在完整皮肤上未显示出刺激迹象。因此，新霉素水凝胶贴剂可能是用于有效伤口愈合的控释制剂的潜在候选者。
