Ferreira Joana, Afonso Julieta, Carneiro Alexandre Lima, Vila Isabel, Cunha Cristina, Roque Susana, Silva Cristina, Mesquita Amílcar, Cotter Jorge, Correia-Neves Margarida, Mansilha Armando, Longatto-Filho Adhemar, Cunha Pedro
Vascular Surgery Department, Centro Hospitalar de Trás-os-Montes e Alto Douro, 5000-508 Vila Real, Portugal.
Life and Health Science Research Institute (ICVS), School of Medicine, University of Minho, 4710-057 Braga, Portugal.
J Cardiovasc Dev Dis. 2023 Jun 25;10(7):271. doi: 10.3390/jcdd10070271.
The prevalence of obesity has doubled, with a concomitant increase in cardiovascular disease. This study aimed to compare the characteristics of visceral, subcutaneous and peri-aortic adipose tissue determined with computed tomography (CT) scans and to correlate them with cardiovascular risk factors, anthropometric measures and medication. An observational and prospective study was conducted, and 177 subjects were included. Peri-aortic adipose tissue had the highest density, while the subcutaneous adipose tissue had the lowest. The density of subcutaneous adipose tissue differs from the density of visceral ( = 0.00) and peri-aortic adipose tissue ( = 0.00). Smokers/ex-smokers had a lower area ( = 0.00) and density ( = 0.02) of subcutaneous adipose tissue. Multiple linear regression analysis showed that sex was a predictor of subcutaneous adipose tissue area (β = -0.27, t = -3.12, = 0.00) but smoking habits were not. After controlling for sex, we found that the association between smokers/ex-smokers and area of subcutaneous adipose tissue was lost, but the association with density persisted. Patients with hypertension had a higher visceral adipose tissue area, and this relationship was maintained even after adjusting for gender. Peri-aortic adipose tissue is similar to visceral and distinct from subcutaneous adipose tissue. Cardiovascular risk factors have different influences in distinct adipose compartments.
肥胖的患病率已翻倍，同时心血管疾病也有所增加。本研究旨在比较通过计算机断层扫描（CT）确定的内脏、皮下和主动脉周围脂肪组织的特征，并将它们与心血管危险因素、人体测量指标和药物治疗相关联。进行了一项观察性前瞻性研究，纳入了177名受试者。主动脉周围脂肪组织密度最高，而皮下脂肪组织密度最低。皮下脂肪组织的密度与内脏脂肪组织（P = 0.00）和主动脉周围脂肪组织（P = 0.00）的密度不同。吸烟者/戒烟者的皮下脂肪组织面积较小（P = 0.00）且密度较低（P = 0.02）。多元线性回归分析表明，性别是皮下脂肪组织面积的预测因素（β = -0.27，t = -3.12，P = 0.00），但吸烟习惯不是。在控制性别后，我们发现吸烟者/戒烟者与皮下脂肪组织面积之间的关联消失，但与密度的关联仍然存在。高血压患者的内脏脂肪组织面积较大，即使在调整性别后这种关系依然存在。主动脉周围脂肪组织与内脏脂肪组织相似，与皮下脂肪组织不同。心血管危险因素在不同的脂肪隔室中有不同的影响。
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