Li Yi, Wang Xin, Dong Haonan, Xia Qingyou, Zhao Ping
Integrative Science Center of Germplasm Creation in Western China (CHONGQING) Science City, Biological Science Research Center, Southwest University, Chongqing 400715, China.
Insects. 2023 Jul 24;14(7):658. doi: 10.3390/insects14070658.
Starvation imposes significant stress on animal survival and development, resulting in organ damage within the organism. The brain, being one of the most vital organs in animals, plays a crucial role in coordinating the physiological functions of other organs. However, performing brain experiments on the human body is challenging. In this work, we selected the silkworm, a model Lepidoptera organism, due to its favorable characteristics. A comprehensive transcriptome analysis was conducted on the brain of silkworm subjected to starvation treatment. The analysis of differentially expressed genes revealed significant alterations in 330 genes following the period of starvation. Through an enrichment analysis, we successfully identified pathways associated with metabolism, hormones, immunity, and diseases. Our findings highlight the transcriptional response of the brain to starvation, providing valuable insights for comprehending the impact of starvation stress in other animals.
饥饿对动物的生存和发育施加了巨大压力，导致生物体内的器官损伤。大脑作为动物体内最重要的器官之一，在协调其他器官的生理功能方面发挥着关键作用。然而，在人体上进行脑部实验具有挑战性。在这项工作中，我们选择了家蚕这种模式鳞翅目生物，因其具有良好的特性。对经过饥饿处理的家蚕大脑进行了全面的转录组分析。对差异表达基因的分析显示，饥饿一段时间后330个基因发生了显著变化。通过富集分析，我们成功鉴定出了与代谢、激素、免疫和疾病相关的通路。我们的研究结果突出了大脑对饥饿的转录反应，为理解饥饿应激对其他动物的影响提供了有价值的见解。
