Sakai Katsuya, Kawasaki Tsubasa, Kiminarita Hiroya, Ikeda Yumi
Department of Physical Therapy, Faculty of Health Sciences, Tokyo Metropolitan University, Tokyo 116-8551, Japan.
Department of Physical Therapy, School of Health Sciences, Tokyo International University, Kawagoe 350-1197, Japan.
Medicines (Basel). 2023 Jul 6;10(7):42. doi: 10.3390/medicines10070042.
This report described two cases with clear longitudinal changes in motor estimation error (difference between the motor imagery and motor execution) and their progression and motor and activities of daily living (ADL) function changes in patients with PD.
Patient 1 was a 68-year-old man (Hoehn and Yahr [H and Y] stage: IV, diagnosed with PD for 11.8 years) and patient 2 was a 68-year-old woman (H and Y stage: II, diagnosed with PD for 9.6 years). Imagined two-step test (iTST), two-step test (TST), and PD-related assessments (Unified Parkinson's Disease Rating Scale [UPDRS], and Freezing of Gait Questionnaire [FOGQ]) were assessed at baseline and after 6 months. Motor estimation error was calculated as the iTST distance minus TST distance.
In patient 1, motor estimation error was greater after 6 months (baseline: 5.7 [4.8%]/after 6 months: 25.7 cm [26.1%]). Moreover, UPDRS and FOGQ total scores deteriorated after 6 months (UPDRS total: 29/34 point, and FOGQ: 9/16 point). Conversely, in patient 2, motor estimation error did not change notably (-3.6 [7.6%]/-2.5 cm [7.0%]), while UPDRS and FOGQ total scores improved after 6 months (UPDRS total: 17/12 point, and FOGQ: 6/1 point).
This report indicated that greater motor estimation error may be associated with declining motor and ADL function and disease progression in patients with PD.
本报告描述了两例帕金森病（PD）患者运动估计误差（运动想象与运动执行之间的差异）出现明显纵向变化及其进展情况，以及运动和日常生活活动（ADL）功能的变化。
患者1为一名68岁男性（霍恩和雅尔[H和Y]分期：IV期，诊断为PD 11.8年），患者2为一名68岁女性（H和Y分期：II期，诊断为PD 9.6年）。在基线期和6个月后评估想象两步试验（iTST）、两步试验（TST）以及与PD相关的评估（统一帕金森病评定量表[UPDRS]和步态冻结问卷[FOGQ]）。运动估计误差计算为iTST距离减去TST距离。
在患者1中，6个月后运动估计误差更大（基线期：5.7[4.8%]/6个月后：25.7厘米[26.1%]）。此外，6个月后UPDRS和FOGQ总分恶化（UPDRS总分：29/34分，FOGQ：9/16分）。相反，在患者2中，运动估计误差无明显变化（-3.6[7.6%]/-2.5厘米[7.0%]），而6个月后UPDRS和FOGQ总分改善（UPDRS总分：17/12分，FOGQ：6/1分）。
本报告表明，更大的运动估计误差可能与PD患者运动和ADL功能下降以及疾病进展相关。
